Brought to you by:
Bioelectricity – Professor Pedro Irazoqui
A self-paced course brought to you by nanoHUB-U.
The text for this course is “Neuroscience” by Purves, et al. The text is available through the following link:
This five-week short course aims to introduce students to bioelectricity using a unique, “bottom up” approach.
Scientific Overview Video
Fundamentals of bioelectricity of the mammalian nervous system. Passive and active forms of electric signaling in both intra and inter-cellular communication at the atomic, molecular, and engineered device level. Mathematical analysis including the Nernst equation, core conductors, cable theory, and the Hodgkin-Huxley Model of the action potential. Neuromodulation with nano-engineered sensors and actuators.
All course materials are available by selecting "Go to Course" on the right.
Week 1: Introduction to the Nervous System by Pedro Irazoqui
- L1.1: Basic Organization of CNS &amp;amp; PNS
- L1.2: Simple Neural Circuits (VOR, stretch)
- L1.3: Electrical Signals in Cells
- L1.4: Resting Potential of Neuron Membranes
- L1.5: Nernst Equation
Week 2: Chemical Basis of Electrical Signals by Pedro Irazoqui
- L2.1: TIC and DOC
- L2.2: Time &amp;amp; Space in Propagating Signals
- L2.3: Ion Channels
- L2.4: Post-synaptic Receptors
- L2.5: Neurotransmitters and Pathology
Week 3: Models of Biological Conductors by Pedro Irazoqui
- L3.1: Electrical Variables in Cells
- L3.2: Core Conductor Model
- L3.3: Observations from Action Potentials
- L3.4: Derivation of the Cable Model
- L3.5: Time-dependent Solutions
Week 4: The Hodgkin-Huxley Model by Pedro Irazoqui
- L4.1: Alan Hodgkin and Andrew Huxley
- L4.2: Ionic Conductances
- L4.3: Derivation of the Hodgkin-Huxley Equation
- L4.4: Insights from Hodgkin-Huxley
- L4.5: Further insights from Hodgkin-Huxley
Week 5: Applications of Bioelectricity by Pedro Irazoqui
- L5.1: Parkinson’s Disease
- L5.2: Epilepsy
- L5.3: Drug Addiction
- L5.4: Targeted Muscle Reinnervation
- L5.5: Optogenetics
The objective of this course is to establish a background and to dig deeper into some of the applications of bioelectricity to medicine. Students will learn about how bioelectricity can be used to record and control the way the body electric behaves.
Who Should Take the Course?
Students who are interested in learning about relating the systems of the human body that involve or communicate with bioelectrical systems, including the heart, brain, muscles, and the neuromuscular system that connects them all together.
The prerequisites of this course are freshmen physics to understand the basics of circuits, resistors and capacitors, and differential equations to follow along with the mathematics and the derivations of the core conductor cable and the Hodgkin-Huxley equations.