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BME 695N: Engineering Nanomedical Systems (Fall 2007)
03 Aug 2007 | Courses | Contributor(s): James Leary
This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and structure …
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Engineering Nanomedical Systems
06 Mar 2006 | Online Presentations | Contributor(s): James Leary
This tutorial discusses general problems and approaches to the design of engineered nanomedical systems. One example given is the engineering design of programmable multilayered nanoparticles (PMNP) to control a multi-sequence process of targeting to rare cells in-vivo, re-targeting to …
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BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems
30 Oct 2007 | Online Presentations | Contributor(s): James Leary
Outline:
Introduction and overview
Some of the advantages of therapeutic genes
Some of the advantages of molecular biosensor feedback control systems
Why a nanodelivery approach is appropriate
The therapeutic gene approach
What constitutes a "therapeutic gene" ?
Transient versus stable …
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BME 695N Lecture 10: Nanomaterials for core design
26 Sep 2007 | Online Presentations | Contributor(s): James Leary
Outline:
Introduction
Core building blocks
Functional cores
Functionalizing the core surface
Ferric oxide cores
Paramagnetic cores
Superparamagnetic cores
Ferric nanorods
Advantages and disadvantages
C60 and carbon nanotubes
Size and structure of C60
Elongation of C60 into …
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BME 695N Lecture 13: Assessing Zeta Potentials
29 Oct 2007 | Online Presentations | Contributor(s): James Leary
Outline:
Introduction – the importance of the zeta potential
Nanoparticle-nanoparticle interactions
Nanoparticle-cell interactions
Part of the initial nanomedical system-cell targeting process
Low zeta potential leads to low serum protein binding and potentially longer circulation
Zeta …