Malvern Instruments Workshop: Nano-particle Characterization Symposium
11 Apr 2012 | Workshops | Contributor(s): James Leary
The key focus of the symposium is to demonstrate how different analytical techniques provide the information needed to advance nanotechnology.
The Importance of Zeta Potential for Drug/Gene Delivery in Nanomedicine
11 Apr 2012 | Online Presentations | Contributor(s): James Leary
Keynote Address
BME 695L Lecture 16: FDA and EPA Regulatory Issues
02 Dec 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.16.1 Introduction and overview16.1.1 How does the FDA think about nanomedical systems?16.1.2 The 2006 Nanotechnology Task Force16.2 Some...
BME 695L Lecture 15: GMP and Issues of Quality Control Manufacture of Nanodelivery Systems
See references below for related reading.15.1 Overview15.1.1 What does cGMP mean?15.1.2 Why GMP? Controlling processes means more predictable...
BME 695L Lecture 14: Designing and Testing Integrated Nanomedical Systems
22 Nov 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.14.1 Introduction to integrated designs14.1.1 “Total design” but there is some order in the design process14.1.2 A brief outline of the total design...
BME 695L Lecture 13: Designing Nanomedical Systems (NMS) for In-vivo Use
See references below for related reading.13.1 Bringing in-vivo considerations into NMS design13.1.1 the in-vitro to ex-vivo to in-vivo paradigm 13.1.1.1 In-vitro - importance of choosing...
BME 695L Lecture 12: Assessing Drug Efficacy and Nanotoxicity at the Single Cell Level
See references below for related reading.12.1 Introduction to measures of efficacy for nanomedicine12.1.1 for evaluation purposes, does structure/size reveal function?12.1.2 nanomedical treatment at the single cell...
BME 695L Lecture 11: Assessing Nanotoxicity at the Single Cell Level
27 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.11.1 Need for single cell measures of nanotoxicity11.1.1 There is more than one way for a cell to die...11.1.2 "Necrosis" vs. "Apoptosis"11.1.3 There...
BME 695L Lecture 10: Nanodelivery of Therapeutic Genes and Molecular Biosensor Feedback Control Systems
26 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.10.1 Introduction and overview10.1.1 Some of the advantages of therapeutic genes10.1.2 Some of the advantages of molecular biosensor feedback control...
BME 695L Lecture 9: Challenges of Proper Drug Dosing with Nanodelivery Systems
19 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.9.1 Overview of drug dosing problem9.1.1 Problems of scaling up doses from animal systems9.1.2 Basing dosing on size, area, weight of...
BME 695L Lecture 8: Surface Chemistry: attaching nanomedical structures to the core
12 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.8.1 Introduction8.1.1 attachment strategies typically depend on core composition8.1.2 but the attachment strategy should not drive the core...
BME 695L Lecture 7: Assessing Zeta Potentials
03 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.7.1 Introduction – the importance of the zeta potential7.1.1 nanoparticle-nanoparticle interactions7.1.2 nanoparticle-cell interactions7.1.3 part of...
BME 695L Lecture 6: Normal & Facilitated Cell Entry Mechanisms
04 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.6.1 Introduction6.1.1 the general problem of cell entry6.1.2 choosing modes of cell entry6.1.3 how does Nature do it?...
BME 695L Lecture 5: Nanomaterials for Core Design
See references below for related reading.5.1 Introduction5.1.1 core building blocks5.1.2 functional cores5.1.3 functionalizing the core surface5.2 Ferric...
BME 695L Lecture 4: Cell Targeting and its Evaluation
See references below for related reading.4.1 Overview: targeting nanosystems to cells4.1.1 antibody targeting4.1.2 peptide targeting4.1.3 aptamer...
BME 695L Lecture 3: Theranostics and Molecular Imaging
07 Sep 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.3.1 Nanomedical systems – levels of challenges3.1.1 Diagnosis - difficult3.1.2 Therapy – more difficult3.1.3 Both ("Theragnosis") – most...
BME 695L Lecture 2: Designing Nanomedical Systems
31 Aug 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.2.1 Elements of good engineering design2.1.1 Whenever possible, use a general design that has already been tested2.1.2 Whenever possible, take advantage of “biomimicry” –...
BME 695L Lecture 1: Need for New Perspectives on Medicine
See references below for related reading.1.1 Nanotechnology – Why is something so small so big?1.1.1 Definitions of nanotechnology based on size1.1.2 A “bottoms up” rather than “tops down”...
BME 695L: Engineering Nanomedical Systems
31 Aug 2011 | Courses | Contributor(s): James Leary
This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and structure...
Nanomedicine – How Can Something so Small be so Huge for the Future of Healthcare?
17 Jun 2010 | Online Presentations | Contributor(s): James Leary
Dr. James Leary discusses the future on medicine and the impact nanotechnology will have on healthcare.
Optical BioMEMS Microfluidic Technologies for Hand-Held, Point-of-Care, Medical Devices
23 Nov 2009 | Online Presentations | Contributor(s): James Leary
Portable, point-of-care, medical diagnostic devices could provide an important new component in more cost-effective healthcare delivery. Rapid measurements of blood samples during an examination within a doctor’s office or in the field, could allow immediate appropriate treatment of medical...
Design of Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery and Theragnostics
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02 Jul 2008 | Online Presentations | Contributor(s): James Leary
Multi-component and multifunctional nanoparticles hold great promise for drug/gene delivery and simultaneous diagnostics and therapeutics ("theragnostics"). Sophisticated multi-component systems can employ collections of specialized molecules in a nanodelivery system whose actions can be...
Ethics of Stem Cells and Therapeutic Cloning
27 Nov 2007 | Online Presentations | Contributor(s): James Leary
Invited lecture for Purdue University course SOC 573
BME 695N Lecture 21: FDA and EPA Regulatory Issues
Outline:Introduction and overview How does the FDA think about nanomedical systems? The 2006 Nanotechnology Task Force Some details of the Nanotechnology Task Force Report General findings of the report Some initial recommendations of the Task Force Where the FDA may need to meet EPA on nanoscale...
Engineering Nanomedical Systems
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16 Nov 2007 | Online Presentations | Contributor(s): James Leary
This tutorial will cover general problems and approaches to the design of engineered nanomedical systems. An example to be covered is the engineering design of programmable multilayered nanoparticles (PMNP) to control a multi-sequence process of targeting to rare cells in-vivo, re-targeting to...