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Fundamental Limits to the Precision of Multicellular Sensing
27 Jun 2017 | Online Presentations | Contributor(s): Andrew Mugler
Here we address, with both theory and experiments, whether cell-cell communication improves concentration- and gradient-sensing precision. We develop a minimal model of collective sensing by cells that communicate via juxtacrine signaling, in which a small molecule is exchanged between...
MidQBio 2016: 4th Midwest Quantitative Biology Symposium
22 Oct 2016 | Workshops | Contributor(s): Srividya Iyer-Biswas, Tamara L. Kinzer-Ursem, Andrew Mugler
The MidQBio Symposium aims to bring together research groups from around the Midwest with a shared interest in quantitative biology, and to help build a community of these researchers. The symposium provides researchers opportunities to meet periodically to disseminate recent results; network...
Collective Sensing by Communicating Cells
22 Sep 2016 | Online Presentations | Contributor(s): Andrew Mugler
In this talk I will describe recent theoretical and experimental results in which this question is explored in several contexts, including gradient detection by groups of epithelial cells. I will show how communication allows cells to perform qualitatively new behaviors that single cells cannot...
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