Self-association of peptides and proteins: Retrospect and prospects
30 Jul 2008 | Online Presentations | Contributor(s): R. Nagaraj
The ability of peptides and proteins to form aggregates was known from the dawn of protein and peptide chemistry! It was often considered a nuisance and attention was directed towards disaggregating them to ensure dissolution particularly in aqueous solution. X-ray crystallography has indicated that even small peptides can form organized structures consisting of highly ordered oligomers. They exhibit properties such as translocating ions across membranes. With the discovery that many disease conditions arise as a result of protein aggregates, there has been tremendous interest in studying various aspects of protein as well as peptide self-association not necessarily to form crystalline aggregates. In the presentation, various aspects of protein and peptide self-association will be discussed, with particular reference to the work from the speakers lab and their potential application particularly their relevance to pharmaceuticals.