A Primer on Quantum Computing
18 Oct 2006 | Online Presentations | Contributor(s): David D. Nolte
Quantum computers would represent an exponential increase in computing
power...if they can be built. This tutorial describes the theoretical
background to quantum computing, its potential for several specific
applications, and the demanding challenges facing practical
implementation. The field currently suffers from a strange imbalance
with theoretical advances far outstripping experimental demonstration.
The field is poised for a breakthrough that would make quantum circuits
experimentally "accessible", as opposed to the million dollar price tags
attached to most current implementations.
BioDynamic Imaging of Living Tissues
20 Aug 2014 | Online Presentations | Contributor(s): David D. Nolte
In this talk, I will describe two complementary applications of biological interferometry. The first is a multi-mode biomedical imaging approach to study the effects of anti-cancer drugs on living tumour tissue. The living motion inside cells and tissues is the intrinsic (endogenous) contrst agent that allows functional imaging "deep" inside strongly scattering tissue.
In Living Motion: Imaging Cellular Function in Live Tissues
21 Aug 2012 | Online Presentations | Contributor(s): David D. Nolte
Subcellular motions inside live tissue are sensitive indicators of cellular health and cellular response to applied drugs. Digital holography volumetrically captures these motions in tissue dynamics spectroscopy for live-tissue drug screening.
26 Jun 2007 | Online Presentations | Contributor(s): David D. Nolte
While single-molecule detection through fluorescence has now become common-place, there has been no analogous single-molecule capability using direct detection approaches such as interferometry. This limitation is slowly yielding to high-speed interferoemtric detection that is pushing the detection into the small-number limit. In this tutorial, I will outline the basic principles of interferometry and their application to the detection of biomolecules on solid surfaces. The use of high-speed detection on a spinning disc provides an immediate 50 dB noise suppression that is hard to match with high-gain approaches such as surface-plasmon resonance or Fabry-Perots. I will describe the application of spinning-disc interferometry (SDI) on the BioCD to detect antigen binding to immobilized antibodies by establishing phase quadrature conditions in common-path interferometry that is impervious to mechanical perturbations. The high-speed disc approach is developing in parallel with an imaging approach called molecular interferometric imaging (MI2) that directly images molecular patterns on surfaces with sensitivities down to 100 molecules per pixel