BME 695L Lecture 5: Nanomaterials for Core Design

By James Leary

Biomedical Engineering, Purdue University, West Lafayette, IN

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5.1      Introduction
5.1.1    core building blocks
5.1.2    functional cores
5.1.3    functionalizing the core surface

5.2      Ferric oxide cores
5.2.1    paramagnetic cores
5.2.2    superparamagnetic cores
5.2.3    ferric nanorods
5.2.4    advantages and disadvantages

5.3      C60 and carbon nanotubes
5.3.1    size and structure of C60
5.3.2    elongation of C60 into carbon nanotubes
5.3.3    advantages and disadvantages

5.4      Gold cores
5.4.1    gold nanoparticles
5.4.2    gold nanorods
5.4.3    other shapes (e.g. "stars")
5.4.4    gold nanoshells
5.4.5    advantages and disadvantages

5.5      Silica cores
5.5.1    silica nanoparticles
5.5.2    mesoporous silica NP for drug delivery and biosensing
5.5.3    advantages and disadvantages

5.6      Quantum dots
5.6.1    size determines color
5.6.2    good for multicolor fluorescence
5.6.3    importance of coatings
5.6.4    conjugating targeting molecules
5.6.5    examples from studies
5.6.6    finding sub-optical nanoparticles
5.6.7    cytotoxicity issues

5.7      Next generation quantum dots
5.7.1    Water-Soluble Doped ZnSe Nanocrystal Emitters
5.7.2    Organic quantum dots

5.8      Hybrid materials
5.8.1    gold-ferric oxide nanoparticles and nanorods
5.8.2    NIR fluorescent-chitosan polymer-iron oxide core hybrids
5.8.3    dual-modality MRI/NIRF imaging with hybrid nanoparticles


Copyright © 2011, James F. Leary, All rights reserved.


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1083 BME, Purdue University, West Lafayette, IN