BME 695L Lecture 10: Nanodelivery of Therapeutic Genes and Molecular Biosensor Feedback Control Systems

By James Leary

Biomedical Engineering, Purdue University, West Lafayette, IN

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10.1      Introduction and overview
10.1.1    Some of the advantages of therapeutic genes
10.1.2    Some of the advantages of molecular biosensor feedback control systems
10.1.3    Why a nanodelivery approach is appropriate

10.2      The therapeutic gene approach
10.2.1    What constitutes a "therapeutic gene" ?
10.2.2    Transient versus stable expression modes

10.3      Molecular feedback control systems
10.3.1    Drug delivery has traditionally not used feedback controls
10.3.2    Why feedback control might be a very good idea!
10.3.3    Positive or negative feedback?

10.4      Molecular Biosensors as a component of a nanomedicine feedback control system
10.4.1    What is a molecular biosensor?
10.4.2    How a molecular biosensor functions as a therapeutic gene switch

10.5      Building integrated molecular biosensor/gene delivery systems –some examples
10.5.1    Example of a ribozyme/antivirus system
10.5.2    Example of an ARE biosensor/DNA repair system
10.5.3    Example of a feedback-controlled system for treatment of retinopathies


Copyright © 2011, James F. Leary, All rights reserved.


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