This data set contains the collected in vivo pulmonary toxicity results contained in 18 published studies conducted between 2004 and 2011 with single- and multi-walled carbon nanotubes. These data include characterization measurements of the CNT samples as well as observed animal toxic responses through a variety of indicators measured in bronchoalveolar lavage (BAL) fluid.
A total of 995 animals reflecting 135 unique exposure scenarios including control groups are included. The 83 columns contain 33 attributes describing the CNT samples or the exposure parameters and 43 columns reflecting observations of the different toxicological endpoints including distribution parameters.
Funding for this work was provided by the National Science Foundation (NSF) and the Environmental Protection Agency (EPA) under NSF Cooperative Agreement EF-0830093, Center for the Environmental Implications of NanoTechnology (CEINT), the Carnegie Institute of Technology (CIT) Dean's Fellowship, the Prem Narain Srivastava Legacy Fellowship, the Neil and Jo Bushnell Fellowship, and the Steinbrenner Institute for Environmental Education and Research (SEER). Any opinions, findings, conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NSF or the EPA. This work has not been subjected to EPA review and no official endorsement should be inferred.
Elgrabli D. et al. (2008) Toxicology 253:131-136 Ellinger-Ziegelbauer H. et al. (2009) Toxicology 266:16-29 Inoue K. et al. (2008) Soc. For Exp. Bio. and Med. 233:1583-1590 Ma-Hock, L. et al. (2009) Tox. Sci. 112:468-481 Mercer R. et al. (2008) Am. J. Physiol. Lung Cell Mol. Physiol. 294:L87-L97 Muller, J. et al. (2005) Tox. & Appl. Pharma. 207:221-231 Muller, J. et al. (2008) Chem. Res. Tox. 21:1698-1705 Nygaard, U. (2009) Tox. Sci. 109:113-123 Park, E-J et al. (2011) Arch. Toxicol. 04/2011 Pauluhn, J. (2010) Tox. Sci. 113:226-242 Porter D. et al. (2010) Toxicology 269:136-147 Ryman-Rasmussen J. et al. (2008) Am. J. Respir. Cell Mol. Biol. 40:349-358 Shvedova, A. et al. (2005) Am. J. Physiol. Lung Cell Mol. Physiol. 289:698-708 Shvedova, A. et al. (2007) Toxicol. Appl. Pharmacol. 221:339-348 Shvedova, A. et al. (2008) Am. J. Physiol. Lung Cell Mol. Physiol. 295:552-565 Teeguarden, J.G. et al. (2011) Tox. Sci. 120:123-135 Warheit, D. et al. (2004) Tox. Sci. 77:117-125
Gernand, J. and Casman, E. (2012) "A meta-analysis of carbon nanotube pulmonary toxicity studies - How physical dimensions and impurities affect the toxicity of carbon nanotubes" [Submitted]