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[Illinois] Cancer Community Symposium 2012: Arginine Glycine Aspartic Acid Motif Peptide Potentiates the Effect of Oxaliplatin Preventing Colon Cancer Metastasis, Binds to α5 β1 Integrin and Suppresses FAK/ERK/NF-kB Signaling

By Elvira de Mejia

Food Chemistry And Food Toxicology, University of Illinois at Urbana-Champaign, Urbana, IL

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Abstract

Arginine Glycine Aspartic Acid Motif Peptide Potentiates the Effect of Oxaliplatin Preventing Colon Cancer Metastasis, Binds to α5 β1 Integrin and Suppresses FAK/ERK/NF-kB Signaling Lunasin is a promising chemopreventive agent. The objective was to study the effect of lunasin on human colon cancer metastasis using in vitro and in vivo colon cancer model of liver metastasis. Lunasin inhibited the activation of focal adhesion kinase by 28%, 39% and 60% in RKO, HCT-116 and KM12L4 human colon cancer cells, respectively. Lunasin caused an increase in the expression of the inhibitor of kappa B alpha, a decrease in nuclear p50 NF-kB and a reduction in the migration of cancer cells. Lunasin inhibited metastasis and potentiated the effect of oxaliplatin by reducing the expression of proliferating cell nuclear antigen. Liver metastatic nodules were reduced from 28 (PBS) to 14 (lunasin, p = 0.047) while combination of lunasin and oxaliplatin to 5 (p = 0.004). The tumor burden was reduced from 0.13 (PBS) to 0.10 (lunasin, p = 0.039) to 0.04 (lunasin-oxaliplatin, p less than 0.0001). The effect of oxaliplatin in modifying the expression of proteins involved in apoptosis and metastasis was potentiated by lunasin. Lunasin inhibited metastasis by direct binding with alpha-5 beta-1 integrin suppressing FAK/ERK/NF-kB signaling, and potentiated the effect of oxaliplatin in preventing the outgrowth of metastasis.

Cancer Community At Illinois Symposium 2012 April 5-6, 2012: Connecting patient care, research, and scientific advancement Symposium Premise This on-campus research symposium aims to bring together members of campus and the surrounding community to foster interdisciplinary discussions on cancer research and its affects on patient care. In order to increase understanding and awareness, we will discuss in an open forum with research talks, poster presentations, and panel discussions. We invite community members, clinicians, and researchers from UIUC and other Midwest regional institutions from departments ranging from the social sciences to basic sciences to engineering and medicine. The symposium features invited talks from nationally-recognized cancer researchers, oral presentations from UIUC faculty and students, and poster sessions. We encourage student researchers from UIUC and from other regional schools to apply (travel awards are available). About CC@I Symposium The Cancer Community at Illinois (CC@I) Symposium is organized by a group of students on the University of Illinois campus to bridge the areas of social science, basic sciences to engineering and medicine as they relate to cancer. The symposium mission is to: 1) Facilitate interdisciplinary collaboration and understanding that transcends established departmental affiliation; 2) Foster an increased understanding of the social and environmental factors affecting patients; and 3) Develop unique vantage points afforded by interactive dialogue between and among the various cancer research disciplines. In order to accomplish this, the symposium will engage the local patient community through use of the nascent social and support efforts of the Mills Breast Cancer Institute, Carle Hospital, and regional clinical collaborators. If you are interested in other CC@I events or the program in general, please contact cancer-community@illinois.edu

Bio

Dr. Elvira de Mejia has a B.S. degree in Biochemical Engineering from the National Polytechnic Institute (Mexico), M.S. degree in Food Science and Technology from the University of California, Davis and Ph.D. in Plant Biotechnology from the National Polytechnic Institute (Mexico). Dr. de Mejia joined the UIUC faculty in 2002. Dr. de Mejia has published over 110 peer-reviewed publications, over 100 scientific presentations on the areas of Food Science, Food Toxicology, and Chemoprevention at different national and international scientific meetings. She has served as: member of the National Committee for Food Regulations (Mexico); member of scientific evaluation committee of the National Council on Science and Technology (CONACYT, Mexico); President of the Association of Food Technologists (IFT Regional Mexican Chapter, Central Mexico); Advisor on Food Safety for the Mexican Department of Health; Mentor of students and promoter of science among the general public for the National Academy of Science (Mexico); Organizing Committee Member on Trilateral technical summits on "Food Safety in North America" (US-Mexico and Canada); Mentor of the International Intercampus Program (Mexico-Spain); Head and co-founder of several programs in Food Engineering and Food Science in different Universities in Latin America including the Doctoral program in Food Science in the central part of Mexico (PROPAC) where she implemented a vigorous educational and research program in Food Toxicology. She has served as major Professor of more than 30 graduate students at the Master and Doctoral levels, and 25 undergraduate students who have published their thesis in the area of Food Science, particularly Food Toxicology. She has received funding from industry and local and federal government sources, as well as UC-Mexus, Allen Foundation, OAS, AID, and USDA. She believes that "being a scientist and a teacher are one of the best vocations of the world and it is great to leave a legacy of motivated and educated people."

-From Dr. de Mejia's faculty profile

Credits

Authors: Elvira de Mejia*, and Vermont Dia

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Cite this work

Researchers should cite this work as follows:

  • Elvira de Mejia (2012), "[Illinois] Cancer Community Symposium 2012: Arginine Glycine Aspartic Acid Motif Peptide Potentiates the Effect of Oxaliplatin Preventing Colon Cancer Metastasis, Binds to α5 β1 Integrin and Suppresses FAK/ERK/NF-kB Signaling," http://nanohub.org/resources/13942.

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Location

Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL

Submitter

Obaid Sarvana, NanoBio Node

University of Illinois at Urbana-Champaign

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