[Illinois]: BioNanotechnology Seminar Series Fall 2012: Towards the Development of Click Chemistry-Mediated Nanomedicine for Cancer Cell Targeting
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We have developed nanoparticles that are functionalized with highly-strained and highly-reactive cycloalkynes. These functionalized nanoparticles undergo spontaneous, reagent-free covalent reaction with metabolically incorporated azido-sugars on the cell surface, which is anticipated to promote nanoparticles internalization through endocytosis. This approach is expected to allow high cellular uptake of the nanoparticles while triggering a lower immune response than nanoparticles functionalized with protein- or aptamer-based targeting ligands. Here we report our progress towards achieving these goals.
University of Illinois at Urbana-Champaign
Vahid is a PhD student in the Department of Chemical and Biomolecular Engineering at the University of Illinois at Urbana-Champaign. His advisers are Jianjun Cheng (MatSE) and Mary Kraft(ChBE).
Researchers should cite this work as follows:
Vahid Mirshafiee; NanoBio Node (2012), "[Illinois]: BioNanotechnology Seminar Series Fall 2012: Towards the Development of Click Chemistry-Mediated Nanomedicine for Cancer Cell Targeting," https://nanohub.org/resources/16104.
MNTL 1000, University of Illinois Urbana Champaign, Urbana, IL