[Illinois] BioNanotechnology Seminar Series Fall 2012: Towards the Development of Click Chemistry-Mediated Nanomedicine for Cancer Cell Targeting
We have developed nanoparticles that are functionalized with highly-strained and highly-reactive cycloalkynes. These functionalized nanoparticles undergo spontaneous, reagent-free covalent reaction with metabolically incorporated azido-sugars on the cell surface, which is anticipated to promote nanoparticles internalization through endocytosis. This approach is expected to allow high cellular uptake of the nanoparticles while triggering a lower immune response than nanoparticles functionalized with protein- or aptamer-based targeting ligands. Here we report our progress towards achieving these goals.
Vahid is a PhD student in the Department of Chemical and Biomolecular Engineering at the University of Illinois at Urbana-Champaign. His advisers are Jianjun Cheng (MatSE) and Mary Kraft(ChBE).He earned his B.S. from Sharif University of Technology in Iran. His area of interest is nanomedicine and targeted drug delivery.
Researchers should cite this work as follows:
Vahid Mirshafiee (2012), "[Illinois] BioNanotechnology Seminar Series Fall 2012: Towards the Development of Click Chemistry-Mediated Nanomedicine for Cancer Cell Targeting," http://nanohub.org/resources/16104.
MNTL 1000, University of Illinois Urbana Champaign, Urbana, IL