[Illinois] BioEngineering Seminar Series: Modular Engineering of Tissue Reconstruction Scaffolds
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Tissue engineering scaffolds must fulfill a plethora of requirements to support tissue regeneration, including replication of complex defect geometry, provision of mechanical support, provision of adequate mass transport, and delivery of biologic cues to enhance tissue regeneration. On top of this, scaffolds allow surgeons flexibility and ease of use in the operating room. Such requirements raise a number of design and manufacturing challenges for successful translation of scaffolds for clinical use, including definition of . In this talk I will present the concept of modular engineering for tissue reconstruction scaffolds. Modularity implies the ability to create complex scaffold systems from simpler scaffold components. For design, modularity relies on the use of multiscale porous architecture designs integrated with anatomical shape using Boolean operations. For manufacturing, modularity implies the use of multiple processes from 3D printing to protein conjugation to create scaffolds with complex anatomic shape that with hetereogeneous porous architecture that deliver proteins and/or genes in controlled 3D locations. For surgical implementation, modularity implies physical scaffold modules that can be assembled in the operating room. Finally, we demonstrate that modularity allows us to have rigorous control over scaffold architecture and biologic delivery, enabling us to rigorously test design hypotheses concerning how scaffold design affects tissue regeneration. Examples ranging from in vitro to pre-clinical studies to clinical implementation will be presented. We finish by discussing how modularity can simplify regulatory implementation of scaffold therapies.
From the University of Michigan, Biomedical Engineering Dept.:
Professor Hollister's research group, the Scaffold Tissue Engineering Group (STEG), develops biomaterial platform systems (termed scaffolds) for tissue reconstruction. The STEG specifically focuses on the computational design, manufacturing and pre-clinical testing of degradable scaffold material systems. These system can be used to deliver stem cells, genes and proteins to regenerate tissue defects resulting from disease (for instance due to tumor resection), trauma, or abnormal development. Specific clinical applications include spine fusion and disc repair, craniomaxillofacial (CMF) reconstruction, orthopaedic trauma and joint reconstruction, and cardiovascular reconstruction. STEG patented technology was recently used to found the spin-off company Tissue Regeneration Systems, Inc. (TRS) that focuses on commercializing these degradable material systems as structural biologic delivery devices.
Researchers should cite this work as follows:
Scott Hollister (2013), "[Illinois] BioEngineering Seminar Series: Modular Engineering of Tissue Reconstruction Scaffolds," https://nanohub.org/resources/16707.