[Illinois] ECE 416 Applications II

By Brian Cunningham

Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Il

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           In this lecture, ideas are presented for how biosensors may capture biomolecules. One of these ideas was the Anthrex Spore Detection which identified by the outer coat of the protein. A bioselective layer was a way to produce a biosensor that recognizes a particular molecule. Then, four immobilization methods were discussed: Adsorption, Covalent Binding, Entrapment, and Membrane Confinement.


My research group is focused on the application of sub-wavelength optical phenomena and fabrication methods to the development of novel devices and instrumentation for the life sciences. The group is highly interdisciplinary, with expertise in the areas of microfabrication, nanotechnology, computer simulation, instrumentation, molecular biology, and cell biology. In particular, we are working on biosensors based upon photonic crystal concepts that can either be built from low-cost flexible plastic materials, or integrated with semiconductor-based active devices, such as light sources and photodetectors, for high performance integrated detection systems.

Using a combination of micrometer-scale and nanometer-scale fabrication tools, we are devising novel methods and materials for producing electro-optic devices with nanometer-scale features that can be scaled for low-cost manufacturing. Many of our techniques are geared for compatibility with flexible plastic materials, leading to applications such as low cost disposable sensors, wearable sensors, flexible electronics, and flexible displays. Because our structures manipulate light at a scale that is smaller than an optical wavelength, we rely on computer simulation tools such as Rigorous Coupled Wave Analysis (RCWA) and Finite Difference Time Doman (FDTD) to model, design, and understand optical phenomena within photonic crystals and related devices.

In addition to fabricating devices, our group is also focused on the design, prototyping, and testing of biosensor instrumentation for high sensitivity, portability, and resolution. Advanced instruments enable high resolution imaging of biochemical and cellular interactions with the ability to monitor images of biochemical interactions as a function of time. Using the sensors and instrumentation, we are exploring new applications for optical biosensor technology including protein microarrays, biosensor/mass spectrometry systems, and microfluidics-based assays using nanoliter quantities of reagents. The methods and systems developed in the laboratory are applied in the fields of life science research, drug discovery, diagnostic testing, and environmental monitoring. -From Professor Cunningham's Faculty Profile

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Researchers should cite this work as follows:

  • Brian Cunningham (2013), "[Illinois] ECE 416 Applications II," http://nanohub.org/resources/16710.

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University of Illinois at Urbana-Champaign, Urbana, IL


NanoBio Node, Obaid Sarvana, George Daley

University of Illinois at Urbana-Champaign


[Illinois] ECE 416 Lecture 5: Applications II
  • Antrhax Spore Detection/Identification 1. Antrhax Spore Detection/Identi… 0
  • Antrhax Spore Detection/Identification 2. Antrhax Spore Detection/Identi… 280.33002396439576
  • Consequences of Errors 3. Consequences of Errors 503.0592868455974
  • Receiver Operating Characteristic ROC Curve Analysis 4. Receiver Operating Characteris… 766.2418560849278
  • ROC Curve 5. ROC Curve 1002.5235221094988
  • ROC Curve 6. ROC Curve 1295.9541115534437
  • ROC Curve Web Demo 7. ROC Curve Web Demo 1472.483540944309
  • Lecture 4: Bioselective Layers 8. Lecture 4: Bioselective Layers 2004.7991096271564
  • Goals for this lecture 9. Goals for this lecture 2040.8735927400367
  • Bioselective Layers 10. Bioselective Layers 2090.7084457000988
  • Desired Characteristics of a Functional Layer 11. Desired Characteristics of a F… 2205.3781944266084
  • Immobilization Methods 12. Immobilization Methods 2289.6759556525831
  • Adsorption 13. Adsorption 2306.90740978554
  • Covalent Binding 14. Covalent Binding 2453.8086554513934
  • Entrapment - Porous Polymer Matrix 15. Entrapment - Porous Polymer Ma… 2593.0239287701725