[Illinois] Bionanotechnology Seminar Series Fall 2012: Mechanical Property Characterization for 3D Collagen Cancer Cell Cultures
The tumor microenvironment is mechanically modified during cancer progression. Imaging of tumor
mechanical environment will provide new information for early cancer diagnosis. However, it is less
clear how the mechanical environment is tuned in cancer. The goal of this study is to understand more
clearly the contrast mechanisms of elasticity images in terms of molecular and cellular activities that
drive cancer. Two imaging modalities (ultrasound and OCT) were implemented. These techniques have
shown promise for discrimination between benign and malignant breast lesions, liver fibrosis staging and
so on. This talk will focus on developing the imaging technique to image the mechanical properties in
3D collagen hydrogel with cancer cell cultures. The success of this new technique will provide
quantitative mechanical property information of ECM in the cellular level, and hopefully could monitor
the mechanical influence during cancer progression and metastasis.
Yue Wang works at Dr Insana's Ultrasonic Imaging Lab at Beckman Institute. She is currently developing a novel shear wave imaging technique which has the potential to bridge molecular, cellular, and tissue biology and to support for medical diagnoses. She is also interested in exploring biological sources of mechanical contrast in cancer development. She hopes to be a professor after graduation and she is also a Mavis Future Faculty Fellow.
Researchers should cite this work as follows:
MNTL 1000, University of Illinois at Urbana-Champaign, Urbana, IL