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The idea of using a nanopore to sequence DNA continues to generate excitement among scientists and entrepreneurs. The spectacular progress in using biological enzymes to enable nanopore sequencing indicates the imminent arrival of nanopores in practical biomedical applications. Even more exciting are the prospects of creating solid-state devices that can read the nucleotide sequence directly from DNA and RNA molecules. In this talk I will describe our recent efforts to model such devices at atomic resolution and develop strategies for electronic readout of the DNA sequence.
University of Illinois at Urbana-Champaign
Aleksei Aksimentiev (UIUC) received his Master's degree in physics from the Ivan Franko Lviv State University, Lviv, Ukraine, and his Ph.D. in chemistry from the Institute of Physical Chemistry, Warsaw, Poland. After a brief postdoctoral training at Mitsui Chemicals, Japan, he joined the Theoretical and Computational Biophysics Group, Urbana, IL, as a Postdoctoral Research Associate. In 2005, he became a Faculty Member of the Physics Department at the University of Illinois, where he is currently a Associate Professor of physics. His research interests include systems that combine biological macromolecules and man-made nanostructures, membrane proteins, and molecular machinery of DNA replication.
Researchers should cite this work as follows:
Aleksei Aksimentiev (2013), "[Illinois] Nanopore Sequencing of DNA," https://nanohub.org/resources/19480.
Materials Research Lab, Room ESB190, University of Illinois at Urbana-Champaign, Urbana, IL