Diffusion weighted Magnetic Resonance Imaging (DW-MRI) is an increasingly popular tool used to probe the microscopic structure of materials and biological tissues. Most studies employing DW-MRI rely on the passive diffusion of water molecules to interrogate the structure of the object or tissue under test. The Intravoxel Incoherent Motion (IVIM) method extends this concept to the quantification of the distribution of blood flow in the capillary beds of living tissue. However, few studies have examined the IVIM method in response to controlled angiogenesis in model organisms. This study examines the application of the IVIM technique to the chick chorioallantoic membrane (CAM) model for quantification of the vascular state of the membrane. Initial experiments demonstrate a qualitative signal derived from the flowing blood. Use of a Bayesian denoising algorithm shows promise in quantifying microcirculatory flow in the CAM membrane.
Alex is a PhD student in Bioengineering at the University of Illinois at Urbana-Champaign.
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