Since establishing her own laboratory in the Department of Molecular and Integrative Physiology, Ann M. Nardulli, Ph.D., has continued to pursue her interests in breast cancer biology and regulation of estrogen-responsive gene expression. Her laboratory demonstrated that binding of the estrogen receptor to discrete DNA binding sites alters receptor conformation, recruitment of regulatory proteins, and estrogen-responsive gene expression. These studies have helped to define how the estrogen-responsive genes in a single cell can be differentially regulated.
More recently, Dr. Nardulli's laboratory has identified novel protein networks that associate with the DNA-bound estrogen receptor and influence its activity. These estrogen receptor-associated proteins include oxidative stress response and DNA repair proteins, each of which alters expression of estrogen-responsive genes in human breast cancer cells. Taken together, these studies with cultured breast cancer cells, normal mammary tissue, and breast cancer tumors have provided evidence that oxidative stress response and DNA repair proteins are involved in the initiation, progression, and metastasis of breast cancer cells.
Dr. Nardulli has been an active participant in the scientific community. She has served on the Editorial Boards of the Journal of Biological Chemistry, Molecular Endocrinology,Endocrine Reviews, and Gene Therapy and Molecular Biology. She has also served as a regular member of the National Institutes of Health (NIH) Molecular & Cellular Endocrinology Study Section and as a member and chair of the U.S. Army Breast Cancer Research Program. Dr. Nardulli has participated as an ad hoc member of the U.S. Army Prostate Cancer Research Program, American Cancer Society, American Heart Association, National Science Foundation, National Institute of Environmental Health Sciences, and various other NIH Study Sections. Dr. Nardulli is currently co-PI on the Midwest Cancer Nanotechnology Center, Director of the University of Illinois Reproductive Biology Program, and a member of The Endocrine Society Advocacy and Public Outreach Core Committee.
Dr. Nardulli received her Ph.D. from the Department of Physiology and Biophysics at the University of Illinois at Urbana-Champaign where she studied the synthesis and degradation of estrogen and progesterone receptors in breast cancer cells. She continued her postdoctoral work in Urbana where she focused on the interaction of the estrogen receptor with DNA.
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