Bioelectronic Devices for Personalized and Precision Medicine: from Wearable Sensors to Medical Nanorobots

By Wei Gao

Mechanical Engineering, California Institute of Technology, Pasadena, CA

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Abstract

The rising clinical and basic research interest in personalized and precision medicine promises to revolutionize traditional medical practices. This presents a tremendous opportunity for developing bio-electronic devices toward predictive analytics and treatment. An ecosystem consisting of emerging wearable biosensors and medical nanorobots can potentially combine health monitoring with delivery of therapy and offer distinct advantages in realizing personalized and precision medicine. In this talk, I will firstly introduce fully-integrated biosensors for multiplexed in-situ perspiration analysis, which can selectively measure a wide spectrum of sweat analytes (e.g. metabolites, electrolytes and heavy metals) and provide insightful information about our health state. Then I will discuss the propulsion and applications of the synthetic nanorobots which have the potential to navigate through the human body for precision therapy internally, without the need for invasive surgical incisions. These bioelectronic devices open the door to a wide range of personalized diagnostic and therapeutic applications.

Bio

Wei Gao Wei Gao is an assistant professor of Medical Engineering at the California Institute of Technology. He received his PhD in Chemical Engineering at University of California, San Diego in 2014 as a Jacobs Fellow and HHMI International Student Research Fellow. In 2014-2017, he was a postdoctoral fellow in the Department of Electrical Engineering and Computer Sciences at the University of California, Berkeley. He is a recipient of 2016 MIT Technology Review 35 Innovators Under 35 (TR35) and 2015 ACS Young Investigator Award (Division of Inorganic Chemistry). His research interests include wearable and flexible electronics, biosensors, nanorobotics and nanomedicine.

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Cite this work

Researchers should cite this work as follows:

  • Wei Gao (2017), "Bioelectronic Devices for Personalized and Precision Medicine: from Wearable Sensors to Medical Nanorobots," http://nanohub.org/resources/27693.

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Location

Room 1001, Birck Nanotechnology Center, Purdue University, West Lafayette, IN

Bioelectronic Devices for Personalized and Precision Medicine: from Wearable Sensors to Medical Nanorobots
  • Bioelectronic Devices for Personalized and Precision Medicine: from Wearable Sensors to Medical Nanorobots 1. Bioelectronic Devices for Pers… 0
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  • Outline 2. Outline 27.961294627961294
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  • Wearable Biosensors for Personalized Medicine 3. Wearable Biosensors for Person… 58.058058058058059
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  • Human Sweat 4. Human Sweat 102.4024024024024
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  • The Current Healthcare Applications of Sweat Test 5. The Current Healthcare Applica… 131.29796463129796
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  • Wearable Sweat Biosensors 6. Wearable Sweat Biosensors 168.80213546880214
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  • Our Technology Fully Integrated Wearable Sensors or Perspiration Analysis 7. Our Technology Fully Integrate… 206.07273940607274
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  • Wearable Sweat Biosensors: System Level Integration 8. Wearable Sweat Biosensors: Sys… 252.01868535201871
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  • System Level Technology Development - I 9. System Level Technology Develo… 342.14214214214218
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  • System Level Technology Development - I 10. System Level Technology Develo… 407.80780780780782
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  • System Level Technology Development - II 11. System Level Technology Develo… 565.49883216549881
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  • Fabrication process flow for the flexible sensors 12. Fabrication process flow for t… 591.92525859192529
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  • Characterization of the sensors 13. Characterization of the sensor… 641.77510844177516
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  • System Level Interference & Temperature Compensation 14. System Level Interference & Te… 661.06106106106108
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  • Repeatability, Stability and Calibration of the Sensors 15. Repeatability, Stability and C… 699.23256589923255
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  • Real time on body sweat analysis 16. Real time on body sweat analys… 934.63463463463472
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  • Real time multiplexed sweat analysis during indoor cycling 17. Real time multiplexed sweat an… 979.01234567901236
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  • Example Application: Dehydration Monitoring 18. Example Application: Dehydrati… 1019.5862529195863
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  • Wearable Sensors for Ca2+ and pH Monitoring 19. Wearable Sensors for Ca2+ and… 1113.4134134134135
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  • Wearable Sensors for Heavy Metal Monitoring 20. Wearable Sensors for Heavy Met… 1199.3326659993327
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  • Characterization of the Microsensor Arrays 21. Characterization of the Micros… 1297.1304637971305
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  • Heavy Metal Monitoring of Body Fluids 22. Heavy Metal Monitoring of Body… 1332.8995662328996
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  • How to Access Sweat Sample Without Exercise? 23. How to Access Sweat Sample Wit… 1390.1234567901236
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  • A Wearable Platform for Sweat Extraction & Sensing 24. A Wearable Platform for Sweat … 1435.9025692359026
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  • Iontophoresis based Sweat Extraction 25. Iontophoresis based Sweat Extr… 1483.6169502836169
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  • Periodical Sweat Extraction using the Wearable Platform 26. Periodical Sweat Extraction us… 1529.4294294294296
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  • Example Applications of Wearable Sweat Biosensors 27. Example Applications of Wearab… 1586.0527193860528
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  • Example applications of wearable sweat biosensors 28. Example applications of wearab… 1702.002002002002
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  • Example applications of wearable sweat biosensors 29. Example applications of wearab… 1761.2612612612613
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  • Wearable Sweat Analysis - Outlook 30. Wearable Sweat Analysis - Outl… 1819.7197197197197
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  • Outline 31. Outline 1859.9933266599935
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  • Nanomotors & Nanomachines 32. Nanomotors & Nanomachines 1873.8738738738739
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  • Fulfill the 'Fantastic Voyage ' Vision – Nanoscale Propulsion 33. Fulfill the 'Fantastic Voyage … 1932.7327327327328
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  • Synthetic Micro/Nanorobots 34. Synthetic Micro/Nanorobots 1993.4267600934268
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  • Highly Efficient Polymer-based Microengines 35. Highly Efficient Polymer-based… 2053.9539539539542
    00:00/00:00
  • The Propulsion of PANI/Pt Microengines 36. The Propulsion of PANI/Pt Micr… 2108.742075408742
    00:00/00:00
  • The Materials Platform: Conducting Polymer Components 37. The Materials Platform: Conduc… 2117.9179179179182
    00:00/00:00
  • The World's Fastest Micro/Nanomotors 38. The World's Fastest Micro/Nano… 2149.94994994995
    00:00/00:00
  • Magnetic Motion Control PANI/Ni/Pt Trilayer Tubular Microrockets 39. Magnetic Motion Control PANI/N… 2178.8455121788456
    00:00/00:00
  • Polymer-based Microengines in Microchannels 40. Polymer-based Microengines in … 2190.1234567901233
    00:00/00:00
  • The Biosensing and Bioisolation using Micro/Nanomotors 41. The Biosensing and Bioisolatio… 2218.8855522188856
    00:00/00:00
  • Selection and Isolation of Cancer Cells in Biological Fluids 42. Selection and Isolation of Can… 2252.1521521521522
    00:00/00:00
  • Lectin Modified Microengines for Bacteria Isolation 43. Lectin Modified Microengines f… 2273.4734734734734
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  • Microrockets with 'Built-In' Boronic Acid Recognition for Isolating Sugars and Cells 44. Microrockets with 'Built-In' B… 2324.0240240240241
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  • Towards In-Situ Fuel 45. Towards In-Situ Fuel 2396.796796796797
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  • The First In Vivo Study Using Synthetic Nanorobots 46. The First In Vivo Study Using … 2426.5932599265934
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  • In Vivo Toxicity of Synthetic Zn Micromotors 47. In Vivo Toxicity of Synthetic … 2486.052719386053
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  • Water Driven Biodegradable Micromotors 48. Water Driven Biodegradable Mic… 2516.6166166166167
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  • Enteric Mg Micromotors in the GI Tract 49. Enteric Mg Micromotors in the … 2561.4614614614616
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  • Micromotor-Enabled Active Drug Delivery for Treatment of Stomach Infection 50. Micromotor-Enabled Active Drug… 2628.7620954287622
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  • Synthetic Nanomotors - Outlook 51. Synthetic Nanomotors - Outlook 2704.8715382048717
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  • Outline 52. Outline 2773.0730730730734
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  • Bioelectronic Devices for Personalized and Precision Medicine 53. Bioelectronic Devices for Pers… 2777.6776776776778
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  • Acknowledgement 54. Acknowledgement 2813.48014681348
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  • Thank you for your attention! Questions? 55. Thank you for your attention! … 2832.2322322322325
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