Innovative Technologies for Spray Drying and Characterization of Pharmaceutical Solids

By Qi (Tony) Zhou

Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN

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Abstract

The 21st century has seen many innovations in manufacturing of pharmaceutical solid, with purposes to improve production efficiency, formulation performance and product stability. As an example, spray drying has been increasingly employed for production of both small- and large-molecule pharmaceutical solids, attributed to the superior production efficiency and formulation flexibility. Over the past decade, there are some innovative technologies have been developed for spray drying. Also, some cutting-edge techniques have been applied to characterize physico-chemical properties of spray-dried solids, aiming to optimize the manufacturability, stability and therapeutic efficacy of the spray-dried products. This talk will summarize some advances in spray drying and characterization of pharmaceutical solids.

Bio

Qi (Tony) Zhou

Dr. Qi (Tony) Zhou joined the Department of Industrial and Physical Pharmacy as an Assistant Professor in 2015. He obtained his PhD from Monash University of Australia in 2011, and received postdoctoral training at the University of Sydney. As a junior faculty, he has published 51 journal articles and secured >$4M research funding from Governments and industry, including NIH R01 and Bill & Melinda Gates Foundation grants. Dr. Zhou’s contributions to the field of pharmaceutical sciences have been recognized by many awards including 2013 Australian Early Career Fellowship, 2014 Australian Endeavour Fellowship, 2015 AAPS Postdoctoral Fellowship, 2016 IPEC Excipient Emerging Researcher Award and 2017 New Investigator Award in Aerosol Medicine. Dr. Zhou is an Editorial Board Member of Journal of Pharmaceutical Sciences, and Guest Editors of Current Pharmaceutical Design and Pharmaceutical Research.

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Cite this work

Researchers should cite this work as follows:

  • Qi (Tony) Zhou (2018), "Innovative Technologies for Spray Drying and Characterization of Pharmaceutical Solids," http://nanohub.org/resources/28234.

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Location

Holiday Inn City Centre, Lafayette, IN

Innovative Technologies for Spray Drying and Characterization of Pharmaceutical Solids
  • Innovative Technologies for Spray Drying and Characterization of Pharmaceutical Solids 1. Innovative Technologies for Sp… 0
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  • Traditional manufacturing of pharmaceutical solids 2. Traditional manufacturing of p… 50.950950950950954
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  • Traditional manufacturing of biological solids 3. Traditional manufacturing of b… 105.03837170503837
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  • Spray drying 4. Spray drying 336.23623623623627
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  • Process analytical technologies for spray drying 5. Process analytical technologie… 369.40273606940275
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  • Spray drying for food manufacturing 6. Spray drying for food manufact… 416.85018351685022
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  • Amorphous solid dispersion 7. Amorphous solid dispersion 508.97564230897564
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  • Spray dried pharmaceutical products for inhalation medicines 8. Spray dried pharmaceutical pro… 579.31264597931272
    00:00/00:00
  • Exubera – spray dried inhaled insulin 9. Exubera – spray dried inhale… 633.76710043376715
    00:00/00:00
  • First FDA-approved sterile spray dried protein products 10. First FDA-approved sterile spr… 698.19819819819827
    00:00/00:00
  • Spray drying offers flexibility for formulation 11. Spray drying offers flexibilit… 720.387053720387
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  • Challenges in Spray drying - Amorphous 12. Challenges in Spray drying - A… 773.70704037370706
    00:00/00:00
  • Co-spray drying ciprofloxacin with colistin 13. Co-spray drying ciprofloxacin … 903.90390390390394
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  • Challenges in Spray drying 14. Challenges in Spray drying 979.51284617951285
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  • Time of flight secondary ion mass spectroscopy 15. Time of flight secondary ion m… 1059.325992659326
    00:00/00:00
  • X-ray Photoelectron Spectroscopy (XPS) 16. X-ray Photoelectron Spectrosco… 1185.1518184851518
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  • Challenges in Spray drying 17. Challenges in Spray drying 1203.5702369035703
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  • Challenges in Spray drying 18. Challenges in Spray drying 1264.064064064064
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  • Moisture sorption caused reduction in aerosol performance 19. Moisture sorption caused reduc… 1347.2138805472139
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  • Untitled: Slide 20 20. Untitled: Slide 20 1375.3753753753754
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  • Comparison between lyophilized and spray dried IgG1 mAb 21. Comparison between lyophilized… 1407.273940607274
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  • Number of Deuterons 22. Number of Deuterons 1468.9356022689356
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  • Mass-spectra results 23. Mass-spectra results 1536.403069736403
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  • Spray freeze drying for heat sensitive biologics 24. Spray freeze drying for heat s… 1613.8471805138472
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  • Atmospheric spray freeze drying 25. Atmospheric spray freeze dryin… 1674.7414080747415
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  • Electrostatic Spray Drying 26. Electrostatic Spray Drying 1717.2839506172841
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  • Acknowledgements 27. Acknowledgements 1750.5839172505839
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