Analyzing Tensile Strength and Fracture Behavior in MCC and Lactose Composite Tablets

By Melanie Hacopian1, Marcial Gonzalez2, Isabel Bojanini, Vidal Lopez3, Jesse Lee Hoffman, Caroline Baker2

1. California State University-Long Beach, Long Beach, CA 2. Purdue University 3. University of California, Riverside

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Abstract

Tablets containing various compositions of MCC and Lactose at several relative densities were subjected to fracture and analyzed for tensile strength. Results showed that as the mass fraction of Lactose increased, tensile strength and fracture strength decreased. Analyzing the tensile strength and fracture pressures of various filler combinations is important in order to determine the proper filler and filler density for a drug in pharmaceutical industry. 

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Researchers should cite this work as follows:

  • Melanie Hacopian, Marcial Gonzalez, Isabel Bojanini, Vidal Lopez, Jesse Lee Hoffman, Caroline Baker (2019), "Analyzing Tensile Strength and Fracture Behavior in MCC and Lactose Composite Tablets," http://nanohub.org/resources/30077.

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