You must login before you can run this tool.
Category
Published on
Abstract
Biological Background
- Hypoxic conditions occur in the center of tumor after tumor cells use and deplete oxygen.
- Hypoxic cells secrete signaling chemicals to induce vascularization, such as vascular epithelial growth factor (VEGF).
Methods
- This model is developed with using agentbased multicellular system simulator which is called PhysiCell [1].
- Cells are changing behavior according to oxygen level. After they become hypoxic, their genes are regulated.
- Our model accounts for this vascularization by increasing VEGF secretion by hypoxic cells.
- Vasculature is controlled by three mechanisms, which are grow, death, and advective flux.
- Blood supplies or uptakes metabolites from microenvironment according to blood target values.
Results
- Tumor has a necrotic core that has nearly no oxygen.
- Cellular layering is formed as: Necrotic (purple), Hypoxic (Green), Normoxic(Red)
- VEGF concentration through tumor has ring-like distribution which is consistent with literature 3
- A small vasculature accumulation near to tumor is observed. This was an expected behavior in order to modeling equations.
Powered by
MathCancer Lab
Sponsored by
National Science Foundation (Award 1720625)
National Institutes of Health (U01-CA232137-01)
Breast Cancer Research Foundation
Jayne Koskinas Ted Giovanis Foundation for Health and Policy
References
[1] PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems. Ghaffarizadeh A, Heiland R, Friedman SH, Mumenthaler SM, Macklin P. PLOS Computational Biology 14(2): e1005991. doi: 10.1371/journal.pcbi.1005991 (2018)
[2] xml2jupyter: Mapping parameters between XML and Jupyter widges. Heiland R, Mishler D, Zhang T, Bower E, Macklin P. bioRxiv 601211; doi: 10.1101/601211 (2019)
[3] Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies C Voutouri, N D. Kirkpatrick, E Chung, F Mpekris, J W. Baish, L L. Munn, D Fukumura, T Stylianopoulos, R K. Jain: PNAS: https://doi.org/10.1073/pnas.1818322116
Cite this work
Researchers should cite this work as follows: