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BME 695N: Engineering Nanomedical Systems (Fall 2007)

By James Leary

Purdue University

Category

Courses

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Abstract

Fall 2007

An updates version of this course is being offered during Fall 2011.

This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and structure of multilayered nanomedical systems, optimizing zeta potentials, design and testing of cell and intracellular targeting systems, in-vivo issues, drug delivery and proper dosing, assessing efficacy of drug/gene delivery, nanotoxicity, animal testing, and regulatory issues. In addition to attending lectures and participating in classroom discussions, students will write and present an original research nanomedical system design project.

This course will serve as an interdisciplinary training for doctoral students in Biomedical Engineering and other fields for a basic understanding of the principles and challenges of nanomedicine.

Handouts:
Course Information and Syllabus
Course Information and Syllabus REVISED
Original Research Project Report
Paper Review Guidelines
3rd Paper Review Instructions

Cite this work

Researchers should cite this work as follows:

  • James Leary (2007), "BME 695N: Engineering Nanomedical Systems (Fall 2007)," http://nanohub.org/resources/3046.

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Lecture Number/Topic Online Lecture Video Lecture Notes Supplemental Material Suggested Exercises
BME 695N Lecture 1: Need for New Perspectives on Medicine View Flash View Notes Outline/Reading
BME 695N Lecture 2: Basic Concepts of Nanomedical Systems View Flash View Notes Outline/Reading
BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design View Flash View Notes Outline/Reading
BME 695N Lecture 4: Designing "Theragnostic" Systems View Flash View Notes Outline/Reading
BME 695N Lecture 5: Cell Targeting View Flash View Notes Outline/Reading
BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo View Flash View Notes Outline/Reading
BME 695N Lecture 7: Normal & facilitated cell entry mechanisms View Flash View Notes Outline/Reading
BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells View Flash View Notes Outline/Reading
BME 695N Lecture 9: Atomic Force Microscopy (AFM) for Nanomedical Systems (cells and nanoparticles) View Flash View Notes
What Helen McNally as guest lecturer.

BME 695N Lecture 10: Nanomaterials for core design View Flash View Notes Outline/Reading
BME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles View Flash View Notes
With Donald E. Bergstrom as guest lecturer.

BME 695N Lecture 12: Introduction to X-ray Photoelectron Spectroscopy and the Examples of Biologically-Relevant Applications View Flash View Notes
With Dmitry Zemlyanov as guest lecturer.

BME 695N Lecture 13: Assessing Zeta Potentials View Flash View Notes Outline/Reading
BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems View Flash View Notes Outline/Reading
BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems View Flash View Notes Outline/Reading
BME 695N Lecture 16: Assessing drug efficacy at the single cell level View Flash View Notes Outline/Reading
BME 695N Lecture 17: Assessing nanotoxicity at the single cell level View Flash View Notes Outline/Reading
BME 695N Lecture 18: Designing nanodelivery systems for in-vivo use View Flash View Notes Outline/Reading
BME 695N Lecture 19: In vivo model systems to study nanomedical approaches to cancer detection and intervention View Flash View Notes Outline/Reading
With Deborah Knapp as guest lecturer.

BME 695N Lecture 20: GMP and issues of quality control manufacture of nanodelivery systems View Flash View Notes Outline/Reading
BME 695N Lecture 21: FDA and EPA Regulatory Issues View Flash View Notes Outline/Reading

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