- Bridging the gap between diagnostics and therapeutics
- How conventional medicine is practiced in terms of diagnostics and therapeutics
- The consequences of separating diagnostics and therapeutics
- A new approach – "theragnostics" (or "theranostics")
- Examples of current theragnostic systems
- Example: Rituxan ("Rituximab)(an example of not using diagnostics to guide the therapy)
- Example 1: Herceptin ("terastuzumab")
- Example 2: Iressa ("Gefitinib)
- How theragnostics relates to Molecular Imaging
- Conventional imaging is not very specific
- Types of In-vivo Imaging
- X-rays, CAT (Computed Axial Tomography) scans
- MRI (magnetic Resonance Imaging)
- PET (Positron Emission Tomography) scans
- "Molecular Imaging"
- Engineering nanomedical systems for simultaneous molecular imaging
- Using nanomedical cores for MRI contrast agents
- Difficulties in using PET probes for nanomedical devices
- Using cell-specific probes for molecular imaging of nanomedical devices
- Breaking the "diffraction limit" – nano-level imaging
- Theragnostic nanomedical devices
- Using nanomedical devices to guide separate therapeutic device
- When might we want to combine diagnostics and therapeutics?
- BJJ Abdullah, Molecular imaging: spawning a new melting-pot for biomedical imaging Biomed Imaging Interv J 2006; 2(4):e28 pages 1-7.
- Chul Ahn, Pharmacogenomics in Drug Discovery and Development, Genomics & Informatics Vol. 5(2) 41-45, 2007
- Eric Betzig, George H. Patterson, Rachid Sougrat, O. Wolf Lindwasser, Scott Olenych, Juan S. Bonifacino, Michael W. Davidson, Jennifer Lippincott-Schwartz, Harald F. Hess Imaging Intracellular Fluorescent Proteins at Nanometer Resolution SCIENCE VOL 313: 1642-1645, 2006
Researchers should cite this work as follows:
James Leary (2007), "BME 695N Lecture 4: Designing "Theragnostic" Systems," https://nanohub.org/resources/3109.
Biomedical Engineering Building, Rm 1083