- The general problem of cell entry
- Choosing modes of cell entry
- How does Nature do it? (biomimetics)
- Non-specific uptake mechanisms
- Pinocytosis by all cells
- Phagocytosis by some cells
- Receptor mediated uptake
- Receptor mediated transport of desired molecules
- Example- transferrin receptor transport of iron for metabolism
- Nanoparticle uptake
- Size matters
- Agglomeration reduces uptake
- Drug delivery by "shedding"
- Extracellular drug delivery by shedding
- Intracellular drug release by shedding
- General reference: Alberts et al., Molecular Biology of the Cell. Garland Science 4th Edition, New York, pp. 747-756. 2002.
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