KIST/PU Phage Display Selection of Tissue-Specific Homing Peptides and their Theragnostic Applications
| Category | Online Presentations |
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| Abstract | Several homing peptides that are specific to tumor cells, artherosclerotic plaques, stroke lesion, apoptotic cells and phosphatidylserine have been isolated by phage display in our laboratory. For example, the Bld-1 peptide is specific to bladder tumor cells and the AP-1 to atherosclerotic plaques. These peptides could be used in targeted delivery either alone or in combination with nanoparticles. We have demonstrated that the Bld-1 peptide can be homing to bladder tumor in vivo and showed a tumor specific PET imaging in rat and mouse models. Moreover, we assembled the Bld-1 peptide with hydrophobically-modified glycol chitosan (HGC) nanoparticles for carrying an anticancer drug and a nearinfrared optical imaging dye for targeted delivery and imaging simultaneously. The AP-1 peptide alone or assembled with HGC nanoparticles could home to atherosclerotic plaques in LDL receptor-deficient mice. These results demonstrate the potential of the homing peptide technology for affinity-based drug targeting and molecular imaging. |
| Bio | 
Byung-Heon Lee is currently an Assistant Professor in Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University (KNU). He received his M.D. license from Korean Medical Association in 1989. He received his B.S. from School of Medicine, KNU in 1989, and his M.S. and Ph.D. in Biochemistry from KNU in 1991 and 1995. He was an Assistant Professor in School of Medicine at Dongguk University in 1996-2001 and a Visiting Investigator in The Burnham Institute for Medical Research, La Jolla, USA in 2001-2003. He joined KNU in 2003.
He is currently a member of Korean Society for Biochemistry and Molecular Biology, the American Association for Cancer Research, and the American Society of Molecular Imaging. His main research interest is “discovery of tissue-specific homing peptides using phage display and their applications to molecular imaging and targeted therapy”. He is currently carrying out projects for the identification of homing peptides to tumor and atherosclerotic plaque and of phosphatidylserine- and blood clotting factor XIIIa-specific peptide ligands. Byung-Heon Lee has published over 30 peer-reviewed papers, 1 book chapter, and 1 review article. He has also filed 4 patents. |
| Credits | In conjunction with: Hai-Yan Hong, Eun-Ju Lee, Hwa Young Lee, Wonjung Kwak, Jeong-Soo Yoo, Kyung-Soon Park, Seulki Lee, Ick-Chan Kwon, Rang-Woon Park, In-San Kim (Korea Institute of Science & Technology, Seoul, Korea). |
| Sponsored by | Korea Institute of Science and Technology Purdue University Purdue University Discovery Park |
| Cite this work | Researchers should cite this work as follows: |
| Time | September 14, 2007 |
| Location | Burton Morgan Building, Room 121, Purdue University, West Lafayette, IN |
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