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KIST/PU Design and Performance of Bioresponsive Nanocarriers with Tunable Reactivity for Drug and Gene Delivery

By Dave Thompson

Purdue University

Published on

Abstract

Our lab has focused on the development of bioresponsive nanocarriers that are designed to release their cargo upon entry into acidic environments such as those found in cellular endosomes and sites of poor circulation. Computational methods have been used to design vinyl ether lipids of varying electron demand. These experiments have guided the synthesis of a family of heterobifunctional vinyl ethers whose reaction kinetics vary by nearly eleven orders of magnitude. We have used this information to develop three different vinyl ether-based carrier systems—(1) targeted PEG liposomes derived from plasmenyl-type lipids; (2) acid-labile PEG-VE-PLA diblock copolymer micelles; and (3) transiently-stable α-CD:PEG polyrotaxanes with cleavable endcaps—for the delivery of enzyme cofactors, small molecule drugs, dual agent imaging agent/photosensitizer cargo and plasmid DNA constructs.

Bio

David H. Thompson Professor Thompson earned a B.S. degree in Chemistry and a B.A. degree in Biology from the University of Missouri-Columbia in 1978. He then attended Colorado State University where he completed his Ph.D. studies on the mechanism of π-allyl nickel (II) halide cross-coupling reactions with organic halides under the guidance of Professor Louis S. Hegedus in 1984. After postdoctoral studies with Professor James K. Hurst from 1984-1987 on the synthesis and photochemical characterization of alkylviologen/vesicle-based artificial photosynthetic systems, he joined the Chemical & Biological Sciences faculty at the Oregon Graduate Institute, where he held the position of Assistant Professor from 1987-1994. Professor Thompson then moved to Purdue University as an Associate Professor and was promoted to the position of Professor of Chemistry in 2001. Professor Thompson has received the Purdue University College of Science Top 10 Teacher Award (2004-2005), has served as the Guest Editor for Advanced Drug Delivery Reviews (2001), chaired the Chemistry of Supramolecules and Assemblies Gordon Research Conference in 2005, served as the Head of the Organic Chemistry Division from 2003-2007 and was appointed as a University Faculty Scholar in 2006. In addition to holding Visiting Professor appointments at the University of British Columbia-Biochemistry (1992), University of Florida-Pharmaceutics (2003), Osaka University-Chemistry (2003), and Japan Advanced Institute of Science and Technology (2005), Professor Thompson has served on the Editorial Advisory Boards of Langmuir (2000-2005) and Bioconjugate Chemistry (2004-present) and is currently a member of the NIH Gene & Drug Delivery study section. Professor Thompson’s research interests are focused on the design, synthesis and performance testing of self-assembling, biofunctional organic materials for 1) drug & gene delivery, 2) supported membrane sensors and 3) protein crystallization.

Credits

In conjuction with: Jong-Mok Kim, Junhwa Shin, Jeroen Van den Bossche, Scott Loethen (Purdue University, West Lafayette, IN).

Supported by NIH GM55266.

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Cite this work

Researchers should cite this work as follows:

  • Dave Thompson (2007), "KIST/PU Design and Performance of Bioresponsive Nanocarriers with Tunable Reactivity for Drug and Gene Delivery," http://nanohub.org/resources/3391.

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Time

Location

Burton Morgan Building, Room 121, Purdue University, West Lafayette, IN

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