X-ray Photoelectron Spectroscopy (XPS) is a powerful research tool for the study of the surface of solids. The technique becomes a widely-used for studies of the properties of atoms, molecules, solids, and surfaces. The main success of the XPS technique is associated with studies of the physical and chemical phenomena on the surface of solids. These investigations were limited by relatively-simple inorganic reactions and not many biologically-related objects were approached by XPS.

In this presentation successful examples of XPS studies of bio-related specimen will be presented. In particularly, the systematic XPS investigation of four peptide-silane and peptide-silane hybrid sol-gel thin films prepared under biologically benign conditions will be reported. This work demonstrates a use for XPS to characterized biologically-inspired surfaces, providing critical information on peptide coverage on the surface of the materials. The chemical shift is discussed. The other example is the self-assembling layers of thiols on Au surface. The usage of Angle resolved XPS is demonstrated. The third discussed example is DNA associated single-walled carbon nanotubes.

Click here to view a companion video tour of the X-ray Photoelectron Spectroscopy (XPS) lab in the Birck Nanotechnology Center.

Researchers should cite this work as follows:

• Dmitry Zemlyanov (2007), "BME 695N Lecture 12: Introduction to X-ray Photoelectron Spectroscopy and the Examples of Biologically-Relevant Applications," https://nanohub.org/resources/3413.

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1. cells
2. course lecture
3. materials science
4. nanomedicine
5. surfaces
6. X-Ray Photoelectron Spectroscopy (XPS)