1. Introduction – the importance of the zeta potential
1. Nanoparticle-nanoparticle interactions
2. Nanoparticle-cell interactions
3. Part of the initial nanomedical system-cell targeting process
4. Low zeta potential leads to low serum protein binding and potentially longer circulation
2. Zeta potential basics
1. What is the zeta potential?
2. How is it measured?
3. Some factors affecting the zeta potential
1. pH
2. Ionic strength
4. Some zeta potential experiences

• Zeta potential measurement using laser Doppler electrophoresis (LDE).
• Why Measure Zeta Potential?.
• Zeta Potential: An Introduction in 30 minutes (PDF).
• Washington, C., "Zeta Potential in Pharmaceutical Formulation" (PDF).
• Using zeta potential to assess protein adsorption to surfactant coated latex (PDF).
• Prow, T.W., Rose, W.A., Wang, N., Reece, L.M., Lvov, Y., Leary, J.F. "Biosensor-Controlled Gene Therapy/Drug Delivery with Nanoparticles for Nanomedicine" Proc. of SPIE 5692: 199 – 208, 2005.

Researchers should cite this work as follows:

• James Leary (2007), "BME 695N Lecture 13: Assessing Zeta Potentials," https://nanohub.org/resources/3418.

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1. zeta potentials