Role of animal models in translational cancer research
Steps from the “bench” to the “bedside”
The in vivo environment (3D, blood supply, microenvironment, immune system)
Types of studies performed in animal models: biodistribution, pharmacokinetics, toxicity, “efficacy”
Expertise of the team needed to take new approaches from the “bench” to the “bedside”
Types of animal models available for translational cancer research
Chemical induced by chemicals, irritants, light/radiation
Syngeneic models
Immunocompromised animals and “foreign” xenografts
Transgenic animals
Naturally-occurring animal models of cancer
Naturally-occurring cancer in dogs as models for human cancer
Models identified to date
Naturally-occurring urinary bladder cancer in dogs
Examples of ongoing studies in pet dogs
Nanomedicine approaches studied in animals in the Knapp / Leary / Bergstrom labs and the Knapp / Frangioni labs
Targeting programmable multilayer nanoparticles in breast cancer
Sentinel lymph node mapping in urinary bladder cancer
Future applications of nanomedicine approaches in urinary bladder cancer
References
Knapp DW, Glickman NW, DeNicola DB, Bonney PL, Lin TL, Glickman LT. Naturally-occurring canine transitional cell carcinoma of the urinary bladder: A relevant model of human invasive bladder cancer. Urol Oncol, 5:47-59, 2000.
Knapp DW, Adams LG, DeGrand AM, Niles JD, Weil AB, O’Donnell MA, Lucroy MD, and Frangioni JV. Sentinel lymph node mapping of invasive urinary bladder cancer in animal models using invisible light. Euro Urology, in press, 2007.
Cite this work
Researchers should cite this work as follows:
Deborah W Knapp (2007), "BME 695N Lecture 19: In vivo model systems to study nanomedical approaches to cancer detection and intervention," https://nanohub.org/resources/3521.