Novel biodegradable & injectable poly(Î²-amino ester)-poly(Îµ-caprolactone)-poly(ethylene glycol)-poly(Îµ-caprolactone)-poly(Î²-amino ester)(PAE-PCL-PEG-PCL-PAE) bi-functional, pH/temperature-sensitive, block copolymer hydrogels were prepared and applied to protein and drug delivery. In this study, human insulin(HI) was loaded into this copolymer as a model protein and the release of HI was investigated in vitro and in vivo. In in vivo experiments, the polymer solution including the complex between HI and copolymer was injected into normal rats and diabetic rats.
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