| Abstract |
The ability of peptides and proteins to form aggregates was known from the dawn of protein and peptide chemistry! It was often considered a nuisance and attention was directed towards disaggregating them to ensure dissolution particularly in aqueous solution. X-ray crystallography has indicated that even small peptides can form organized structures consisting of highly ordered oligomers. They exhibit properties such as translocating ions across membranes. With the discovery that many disease conditions arise as a result of protein aggregates, there has been tremendous interest in studying various aspects of protein as well as peptide self-association not necessarily to form crystalline aggregates. In the presentation, various aspects of protein and peptide self-association will be discussed, with particular reference to the work from the speakers lab and their potential application particularly their relevance to pharmaceuticals. |
| Bio |
Dr. R. Nagaraj has been working on various aspects of ion channels, sorting of proteins in cells, host-defense peptides and peptide/protein self-association.
His research career spans 32 years. He obtained his PhD at the Molecular Biophysics Unit, Indian Institute of Science, Bangalore in 1980 and has been carrying out research and teaching at the Centre for Cellular and Molecular Biology since then. One of the current areas of research is directed towards understanding the biophysical properties governing the self-association of peptides and proteins. He has a US patent and has published extensively in the areas indicated above. He has been invited to speak at several national meetings. |
| Cite this work |
Researchers should cite this work as follows:
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| Time |
01:00 PM, March 13, 2008 |
| Location |
Centre for Cellular and Molecular Biology, Hyderabad, India |
| Tags |
- nano/bio
- pharmaceutical
- proteins
- research seminar
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