Development of Highly Porous Large Polymeric Microparticles for Sustained Local Drug Delivery to the Lung
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In this presentation, I will introduce a new way of making highly porous large polymeric microparticles recently developed in my lab. These microparticles exhibited desirable aerodynamic properties, reduced macrophage uptake, encapsulated a drug efficiently, and provided sustained drug release over 12 hours. This is a simple and efficient method of producing highly porous large particles, which are a promising drug carrier for local inhalational therapy of pulmonary infections often associated with chronic lung disorders, such as cystic fibrosis.
Dr. Yeo has published 25 peer-reviewed papers and 4 book chapters in these fields and received various awards from professional organizations including CRS-3M Drug Delivery Systems Graduate Student/Post-Doc Outstanding Drug Delivery Paper Award (2003) and AAPS Outstanding Graduate Student Research Award in Pharmaceutical Technologies (2004). Dr. Yeo has 2 U.S. Patents and 2 pending patents.
Since her arrival at Purdue in January 2007, she has established an interdisciplinary research program that focuses on engineering therapeutic particles for drug delivery and tissue engineering. As of spring 2008, 12 researchers (1 post-doctoral, 3 graduate, 2 visiting scholars, and 6 undergraduate students) are working in her lab. Dr. Yeo’s research interest spans three areas: (i) Microparticle engineering for pulmonary drug delivery, which is funded by the Cystic Fibrosis Foundation and 3M Drug Delivery Systems; (ii) Developing microcapsules and hydrogels for tissue engineering applications; and (iii) Nanoparticle engineering for tumor-targeted delivery of therapeutic agents. She is actively exploring domestic and international collaboration with physicians, engineers, and industrial researchers.
Researchers should cite this work as follows:
(2008), "Development of Highly Porous Large Polymeric Microparticles for Sustained Local Drug Delivery to the Lung," https://nanohub.org/resources/5028.
Centre for Cellular and Molecular Biology, Hyderabad, India