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Nanobiotechnology – a different perspective
22 Jul 2008 | Online Presentations | Contributor(s): Murali Sastry
The study of the synthesis, exotic properties, assembly/packaging and potential commercial application of nanomaterials is an extremely important topic of research that is expected to have far-reaching global impact. The focus of my talk will be on an emerging branch of nanotechnology that...
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Design of Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery and Theragnostics
02 Jul 2008 | Online Presentations | Contributor(s): James Leary
Multi-component and multifunctional nanoparticles hold great promise for drug/gene delivery and simultaneous diagnostics and therapeutics ("theragnostics"). Sophisticated multi-component systems can employ collections of specialized molecules in a nanodelivery system whose actions can be...
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Use of Ceramic based biomaterials for their application in vitro osteogenic differentiation
30 Jul 2008 | Online Presentations | Contributor(s): Gopal Pande
The use of bioceramics for preparation of implants and prosthesis for applications in orthopedic surgery has been done over several years. Recently new formulations for making substrates and coatings using ceramic material such as alumina, bioglass or zirconia have been done for improved...
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Strategies for Preparation and Manufacture of Polymer-based Nanoparticulate Formulations
21 Jul 2008 | Online Presentations | Contributor(s): Stephen R. Byrn
Nanoparticles hold great promise for drug delivery applications. Several polymer-based formulations containing nanoparticles are in late phase development or on the market. In fact, polymer dispersions provide one of the best methods to prepare nanoparticles of small-molecule organic drugs....
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Self-association of peptides and proteins: Retrospect and prospects
30 Jul 2008 | Online Presentations | Contributor(s): R. Nagaraj
The ability of peptides and proteins to form aggregates was known from the dawn of protein and peptide chemistry! It was often considered a nuisance and attention was directed towards disaggregating them to ensure dissolution particularly in aqueous solution. X-ray crystallography has indicated...
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Self-assembled Monolayer Based Biosensors for Healthcare
06 Aug 2008 | Online Presentations | Contributor(s): B. D. Malhotra
There is increased demand both in developed and the developing countries for ready availability of biosensors [1-5]. In this context, self-assembled monolayer (Scheme I) based biosensors have recently attracted much interest due to their applications in health care, environmemtal, pharmaceuticals...
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Nanomaterials in Biosensing Using Ion Selective Field Effect Transistors and Metal Particles
30 Jul 2008 | Online Presentations | Contributor(s): Nalam Madhusudhana Rao
The multifunctionality, multilayerable architechture and size of nanomaterials offer tremendous opportunities in developing sensing platforms. Ion Selective Field Effect Transistors (ISFET) are solid state and robust pH/ion sensing devices with excellent “voltage vs. ion concentration”...
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Hydration Dynamics in an Amphiphilic Nanostructure under Controlled Hydration Conditions
16 Sep 2008 | Online Presentations | Contributor(s): Amitabha Chattopadhyay
Amphiphilic surfactants self assemble to form reverse (or inverted) micelles in non-polar solvents in which the polar head groups of the surfactant monomers cluster to form a micellar core directed toward the center of the assembly and the hydrophobic tails extend outward into the bulk organic...
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Micro-fabricated Biosensors for Cardiac Diagnostics
30 Jul 2008 | Online Presentations | Contributor(s): V.Ramgopal Rao
In this talk the current status of an ongoing effort in the Electrical Engineering Department at IIT Bombay on the development of an integrated systems to provide point-of-care diagnostic support for cardiovascular diseases will be presented. The system under development monitors the molecular...
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Nanocomposite-Modified Electrodes for Sensing Biological Analytes
30 Jul 2008 | Online Presentations | Contributor(s): V. Yegnaraman
Electrochemical sensing of analytes is mostly enabled by transducers based on potentiometry and amperometry. In this, design of sensing (working) electrode is of utmost importance since it only decides the sensitivity and selectivity features of the sensor. Chemical modification of the electrode...
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Cataract, Myopathy and Keratitis: Possible use of Nanoparticles
16 Sep 2008 | Online Presentations | Contributor(s): Ch. Mohan Rao
Small heat shock proteins are critical for several cellular functions. Failure of heat shock proteins, thus, can cause compromised cellular activity leading to disease. Fungal Keratitis is an eye dieses that can be treated with anti fungal drugs. Availability of the drug at the site of action is...
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So What do Biologist, Biotechnologists & Pharmaceutical Scientist Want With an AFM/SPM Anyway?
11 Sep 2008 | Online Presentations | Contributor(s): Kunal Bose
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Pharmaceutical Manufacturing – Present and Future and What Should be the Role of India?
10 Jul 2008 | Online Presentations | Contributor(s): Prabir K. Basu
Pharmaceutical manufacturing is at a crossroads. There is widespread realization among the regulators and the industry that the current state of high variability and “Quality by Inspection” is no longer adequate. While the industry still largely employs first generation quality management tools,...
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Discovery Park at Purdue University: Engine for Academic and Commercial Growth
10 Jul 2008 | Online Presentations | Contributor(s): Charles Buck, Pankaj Sharma
The Bindley Bioscience Center and Birck Nanotechnology Center at Discovery Park blend life sciences and engineering research to cultivate and support innovative, multi-investigator, interdisciplinary research teams. Discovery Park engages researchers in a broader perspective with applications of...
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Development of Highly Porous Large Polymeric Microparticles for Sustained Local Drug Delivery to the Lung
10 Jul 2008 | Online Presentations | Contributor(s): Yoon Yeo
In this presentation, I will introduce a new way of making highly porous large polymeric microparticles recently developed in my lab. These microparticles exhibited desirable aerodynamic properties, reduced macrophage uptake, encapsulated a drug efficiently, and provided sustained drug release...
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Transforming Pharmaceutical Manufacturing in the 21st Century – Indiana as a Center for Biopharmaceutical Manufacturing
21 Jul 2008 | Online Presentations | Contributor(s): Craig K. Svensson
The pharmaceutical industry is moving from a model of fully integrated pharmaceutical companies to fully networked pharmaceutical companies. In this latter model, major pharmaceutical companies are increasingly relying on partnerships for critical elements in the drug development process. This...
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Multiplex Detection of Cell Surface Markers using Plasmonic Sensors
21 Jul 2008 | Online Presentations | Contributor(s): Joseph M K Irudayaraj
Gold nanorod molecular probes (GNrMPs) were designed and fabricated for multiplex identification of cell surface markers in HBECs. Cells were probed directly using dark field microscopy integrated with a spectral imager for simultaneous detection of up to three surface markers. The...
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Quality by Design and Process Analytical Technology for Pharmaceutical Manufacturing in the 21st Century
21 Jul 2008 | Online Presentations | Contributor(s): Stephen R. Byrn
PAT or Process Analytical Technology is an initiative and guidance from the U.S. FDA to encourage modernization of pharmaceutical manufacturing. In reality, PAT is a subset of the larger concept of Quality by Design which is the implementation of design concepts for pharmaceutical dosage forms...
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Nanomaterials for Bone & Neural Tissue Engineering
11 Sep 2008 | Online Presentations | Contributor(s): S. Swaminathan
Tissue engineering is defined as “the application of biological, chemical and engineering principles towards the repair, restoration or regeneration of tissues using scaffolds, cells, factors alone or in combination.” The goal lis to design and develop biodegradable, biocompatible polymer-ceramic...
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<i>In Vivo</i> Nuclear Magnetic Resonance Imaging and Spectroscopic Investigations of Structure and Function of Rodent Brain
30 Jul 2008 | Online Presentations | Contributor(s): Anant B. Patel
Nuclear Magnetic Resonance Imaging (MRI) is a powerful and a versatile imaging modality for non-invasive characterization of host structure and function. MRI has grown in many directions such as functional MRI, diffusion tensor imaging, chemical shift imaging, which is used to detect single cells...
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Nanohybrids as Sensors and Superstructures
30 Jul 2008 | Online Presentations | Contributor(s): K. George Thomas
We have recently initiated a detailed research program on the design of nanoparticle conjugates of organic/inorganic molecules which enable the coupling of the intrinsic functionalities of molecular systems (binding, self-assembly, switching etc.) with the size and shape dependent optoelectronic...