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This model is capable of making quantitatively accurate predictions of force-extension behavior of a given helix-forming polypeptide sequence including its dependence on pH, temperature and ionic strength.
This application models the tensile mechanics of a given polypeptide molecule void of tertiary structures. The model includes the effects of the helix formation on force-extension behavior of the polypeptide chain. The model is developed based on the helix-coil transition model AGADIR and iPFRC for the stretching response of the random-coil segments. The quantitatively reliable predictions of this model can supplement a single-molecule protein pulling experiment.