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Illinois Nano EP Seminar Series Spring 2011: Interfacing Engineering, Biology, and Medicine at the Micro and Nano Scale
13 Dec 2011 | | Contributor(s):: Rashid Bashir
In this talk, we will present an overviewof our work in Silicon-Based BioMEMS and Bionanotechnology and discuss the state of the art and thefuture challenges and opportunities. We will review a range of projects in our group focused towardsdeveloping rapid detection of biological entities and...
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KIST/PU The Professor’s Challenge: To commercialize or not, that is the question?
06 Dec 2011 | | Contributor(s):: J. Paul Robinson
Outline:Outline the Professors DilemmaShow what the normal criteria for research project direction isDiscuss the Corporate perspectiveDiscuss an example of failed innovationDemonstrate how time can impact an innovative ideaConclusions
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KIST/PU Theragnosis – A New Paradigm of Personalized Medicine
06 Dec 2011 | | Contributor(s):: Ick Chan Kwon
Companion Diagnosis, based on pharmacogenomics, has been recognized as one of most important key representatives of personalized medicine. However, Companion Diagnosis does not provide any clues in developing new ways of therapeutics but it only provides a best choice of drugs based on given...
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Illinois BioNanotechnology Seminar Series Fall 2011: Deconvolving Stiffness in MEMS Pedestal Cell Mass Measurements
05 Dec 2011 | | Contributor(s):: Elise Corbin
The complex relationships between a cell's behavior and the physical properties of both itself and its environment have long been of interest. Specifically, the understanding the mechanisms through which a cell's physical properties influence cell growth, cell differentiation, cell cycle...
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BME 695L Lecture 15: GMP and Issues of Quality Control Manufacture of Nanodelivery Systems
02 Dec 2011 | | Contributor(s):: James Leary
See references below for related reading.15.1 Overview15.1.1 What does cGMP mean?15.1.2 Why GMP? Controlling processes means more predictable...
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BME 695L Lecture 16: FDA and EPA Regulatory Issues
02 Dec 2011 | | Contributor(s):: James Leary
See references below for related reading.16.1 Introduction and overview16.1.1 How does the FDA think about nanomedical systems?16.1.2 The 2006 Nanotechnology Task Force16.2 Some...
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BME 695L Lecture 12: Assessing Drug Efficacy and Nanotoxicity at the Single Cell Level
22 Nov 2011 | | Contributor(s):: James Leary
See references below for related reading.12.1 Introduction to measures of efficacy for nanomedicine12.1.1 for evaluation purposes, does structure/size reveal function?12.1.2 nanomedical treatment at the single cell...
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BME 695L Lecture 11: Assessing Nanotoxicity at the Single Cell Level
27 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.11.1 Need for single cell measures of nanotoxicity11.1.1 There is more than one way for a cell to die...11.1.2 "Necrosis" vs. "Apoptosis"11.1.3 There...
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BME 695L Lecture 8: Surface Chemistry: attaching nanomedical structures to the core
12 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.8.1 Introduction8.1.1 attachment strategies typically depend on core composition8.1.2 but the attachment strategy should not drive the core...
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BME 695L Lecture 6: Normal & Facilitated Cell Entry Mechanisms
04 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.6.1 Introduction6.1.1 the general problem of cell entry6.1.2 choosing modes of cell entry6.1.3 how does Nature do it?...
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BME 695L Lecture 7: Assessing Zeta Potentials
03 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.7.1 Introduction – the importance of the zeta potential7.1.1 nanoparticle-nanoparticle interactions7.1.2 nanoparticle-cell interactions7.1.3 part of...
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BME 695L Lecture 5: Nanomaterials for Core Design
03 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.5.1 Introduction5.1.1 core building blocks5.1.2 functional cores5.1.3 functionalizing the core surface5.2 Ferric...
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BME 695L Lecture 4: Cell Targeting and its Evaluation
03 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.4.1 Overview: targeting nanosystems to cells4.1.1 antibody targeting4.1.2 peptide targeting4.1.3 aptamer...
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BME 695L Lecture 3: Theranostics and Molecular Imaging
07 Sep 2011 | | Contributor(s):: James Leary
See references below for related reading.3.1 Nanomedical systems – levels of challenges3.1.1 Diagnosis - difficult3.1.2 Therapy – more difficult3.1.3 Both ("Theragnosis") – most...
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BME 695L Lecture 1: Need for New Perspectives on Medicine
31 Aug 2011 | | Contributor(s):: James Leary
See references below for related reading.1.1 Nanotechnology – Why is something so small so big?1.1.1 Definitions of nanotechnology based on size1.1.2 A “bottoms up” rather than “tops down”...
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BME 695L Lecture 2: Designing Nanomedical Systems
31 Aug 2011 | | Contributor(s):: James Leary
See references below for related reading.2.1 Elements of good engineering design2.1.1 Whenever possible, use a general design that has already been tested2.1.2 Whenever possible, take advantage of “biomimicry” –...
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Optical BioMEMS Microfluidic Technologies for Hand-Held, Point-of-Care, Medical Devices
23 Nov 2009 | | Contributor(s):: James Leary
Portable, point-of-care, medical diagnostic devices could provide an important new component in more cost-effective healthcare delivery. Rapid measurements of blood samples during an examination within a doctor’s office or in the field, could allow immediate appropriate treatment of medical...
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Cataract, Myopathy and Keratitis: Possible use of Nanoparticles
16 Sep 2008 | | Contributor(s):: Ch. Mohan Rao
Small heat shock proteins are critical for several cellular functions. Failure of heat shock proteins, thus, can cause compromised cellular activity leading to disease. Fungal Keratitis is an eye dieses that can be treated with anti fungal drugs. Availability of the drug at the site of action is...
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Nanomaterials for Bone & Neural Tissue Engineering
11 Sep 2008 | | Contributor(s):: S. Swaminathan
Tissue engineering is defined as “the application of biological, chemical and engineering principles towards the repair, restoration or regeneration of tissues using scaffolds, cells, factors alone or in combination.” The goal lis to design and develop biodegradable, biocompatible...
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The Functional Protocell concept
23 Mar 2008 | | Contributor(s):: Eric Jakobsson
We have invented and created the first prototype of the Functional Protocell.We define the “functional protocell" as a nanoporous solid surrounded by a membrane. The cavities in the solid can be filled with any desired electrolyte up to the limit of solubility. The surrounding membrane can...