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BME 695L Lecture 11: Assessing Nanotoxicity at the Single Cell Level
27 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.11.1 Need for single cell measures of nanotoxicity11.1.1 There is more than one way for a cell to die...11.1.2 "Necrosis" vs. "Apoptosis"11.1.3 There...
BME 695L Lecture 12: Assessing Drug Efficacy and Nanotoxicity at the Single Cell Level
22 Nov 2011 | | Contributor(s):: James Leary
See references below for related reading.12.1 Introduction to measures of efficacy for nanomedicine12.1.1 for evaluation purposes, does structure/size reveal function?12.1.2 nanomedical treatment at the single cell...
BME 695L Lecture 15: GMP and Issues of Quality Control Manufacture of Nanodelivery Systems
02 Dec 2011 | | Contributor(s):: James Leary
See references below for related reading.15.1 Overview15.1.1 What does cGMP mean?15.1.2 Why GMP? Controlling processes means more predictable...
BME 695L Lecture 16: FDA and EPA Regulatory Issues
See references below for related reading.16.1 Introduction and overview16.1.1 How does the FDA think about nanomedical systems?16.1.2 The 2006 Nanotechnology Task Force16.2 Some...
BME 695L Lecture 1: Need for New Perspectives on Medicine
31 Aug 2011 | | Contributor(s):: James Leary
See references below for related reading.1.1 Nanotechnology – Why is something so small so big?1.1.1 Definitions of nanotechnology based on size1.1.2 A “bottoms up” rather than “tops down”...
BME 695L Lecture 2: Designing Nanomedical Systems
See references below for related reading.2.1 Elements of good engineering design2.1.1 Whenever possible, use a general design that has already been tested2.1.2 Whenever possible, take advantage of “biomimicry” –...
BME 695L Lecture 3: Theranostics and Molecular Imaging
07 Sep 2011 | | Contributor(s):: James Leary
See references below for related reading.3.1 Nanomedical systems – levels of challenges3.1.1 Diagnosis - difficult3.1.2 Therapy – more difficult3.1.3 Both ("Theragnosis") – most...
BME 695L Lecture 4: Cell Targeting and its Evaluation
03 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.4.1 Overview: targeting nanosystems to cells4.1.1 antibody targeting4.1.2 peptide targeting4.1.3 aptamer...
BME 695L Lecture 5: Nanomaterials for Core Design
See references below for related reading.5.1 Introduction5.1.1 core building blocks5.1.2 functional cores5.1.3 functionalizing the core surface5.2 Ferric...
BME 695L Lecture 6: Normal & Facilitated Cell Entry Mechanisms
04 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.6.1 Introduction6.1.1 the general problem of cell entry6.1.2 choosing modes of cell entry6.1.3 how does Nature do it?...
BME 695L Lecture 7: Assessing Zeta Potentials
See references below for related reading.7.1 Introduction – the importance of the zeta potential7.1.1 nanoparticle-nanoparticle interactions7.1.2 nanoparticle-cell interactions7.1.3 part of...
BME 695L Lecture 8: Surface Chemistry: attaching nanomedical structures to the core
12 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.8.1 Introduction8.1.1 attachment strategies typically depend on core composition8.1.2 but the attachment strategy should not drive the core...
BME 695N Lecture 10: Nanomaterials for core design
out of 5 stars
26 Sep 2007 | | Contributor(s):: James Leary
Outline:IntroductionCore building blocksFunctional coresFunctionalizing the core surfaceFerric oxide coresParamagnetic coresSuperparamagnetic coresFerric nanorodsAdvantages and disadvantagesC60 and carbon nanotubesSize and structure of C60Elongation of C60 into carbon nanotubesAdvantages and...
BME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles
30 Sep 2007 | | Contributor(s)::
With Donald E. Bergstrom as guest lecturer.
BME 695N Lecture 17: Assessing nanotoxicity at the single cell level
06 Nov 2007 | | Contributor(s):: James Leary
Outline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned...
BME 695N Lecture 1: Need for New Perspectives on Medicine
03 Aug 2007 | | Contributor(s):: James Leary
Outline:The Progression of MedicineConventional "modern" medicine "Personalized" or "molecular" medicineNanomedicine "single-cell" medicineHow Conventional Medicine Works for Diagnosis of DiseaseIdentification of the "diseased state"Simple measurements of body structure and functionFollow-up...
BME 695N Lecture 21: FDA and EPA Regulatory Issues
27 Nov 2007 | | Contributor(s):: James Leary
Outline:Introduction and overview How does the FDA think about nanomedical systems? The 2006 Nanotechnology Task Force Some details of the Nanotechnology Task Force Report General findings of the report Some initial recommendations of the Task Force Where the FDA may need to meet EPA on...
BME 695N Lecture 2: Basic Concepts of Nanomedical Systems
28 Aug 2007 | | Contributor(s):: James Leary
Outline: Features of NanomedicineBottoms up rather than top down approach to medicine Nano-tools on the scale of molecules Cell-by-cell repair approach – regenerative medicine Feedback control system to control drug dosing Elements of good engineering designWhenever possible, use a general...
BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design
29 Aug 2007 | | Contributor(s):: James Leary
Outline:Nanomedical systems – levels of challengesEssential elements of a nanomedical systemRequirements for specific cell targetingConsequences of mis-targetingEngineering around the consequences of mis-targetingSome ways to lower mis-targeting to non-diseased cells
BME 695N Lecture 4: Designing "Theragnostic" Systems
04 Sep 2007 | | Contributor(s):: James Leary
Outline:Bridging the gap between diagnostics and therapeuticsHow conventional medicine is practiced in terms of diagnostics and therapeuticsThe consequences of separating diagnostics and therapeuticsA new approach – "theragnostics" (or "theranostics")Examples of current theragnostic...