-
BME 695L Lecture 11: Assessing Nanotoxicity at the Single Cell Level
27 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading. 11.1 Need for single cell measures of nanotoxicity 11.1.1 There is more than one way for a cell to die... 11.1.2 "Necrosis" vs. "Apoptosis" …
https://nanohub.org/resources/12264
-
BME 695L Lecture 12: Assessing Drug Efficacy and Nanotoxicity at the Single Cell Level
22 Nov 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading. 12.1 Introduction to measures of efficacy for nanomedicine 12.1.1 for evaluation purposes, does structure/size reveal function? 12.1.2 …
https://nanohub.org/resources/12392
-
BME 695L Lecture 15: GMP and Issues of Quality Control Manufacture of Nanodelivery Systems
02 Dec 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading. 15.1 Overview 15.1.1 What does cGMP mean? 15.1.2 Why GMP? Controlling processes means more predictable outcomes… 15.1.3 Enforcement …
https://nanohub.org/resources/12497
-
BME 695L Lecture 16: FDA and EPA Regulatory Issues
02 Dec 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading. 16.1 Introduction and overview 16.1.1 How does the FDA think about nanomedical systems? 16.1.2 The 2006 Nanotechnology Task Force 16.2 …
https://nanohub.org/resources/12498
-
BME 695L Lecture 1: Need for New Perspectives on Medicine
31 Aug 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading. 1.1 Nanotechnology – Why is something so small so big? 1.1.1 Definitions of nanotechnology based on size 1.1.2 A “bottoms up” rather …
https://nanohub.org/resources/11965
-
BME 695L Lecture 2: Designing Nanomedical Systems
31 Aug 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading. 2.1 Elements of good engineering design 2.1.1 Whenever possible, use a general design that has already been tested 2.1.2 Whenever …
https://nanohub.org/resources/11968
-
BME 695L Lecture 3: Theranostics and Molecular Imaging
07 Sep 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading. 3.1 Nanomedical systems – levels of challenges 3.1.1 Diagnosis - difficult 3.1.2 Therapy – more difficult 3.1.3 Both …
https://nanohub.org/resources/11990
-
BME 695L Lecture 4: Cell Targeting and its Evaluation
03 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading. 4.1 Overview: targeting nanosystems to cells 4.1.1 antibody targeting 4.1.2 peptide targeting 4.1.3 aptamer targeting 4.1.4 …
https://nanohub.org/resources/12056
-
BME 695L Lecture 5: Nanomaterials for Core Design
03 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading. 5.1 Introduction 5.1.1 core building blocks 5.1.2 functional cores 5.1.3 functionalizing the core surface 5.2 Ferric oxide …
https://nanohub.org/resources/12057
-
BME 695L Lecture 6: Normal & Facilitated Cell Entry Mechanisms
04 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading. 6.1 Introduction 6.1.1 the general problem of cell entry 6.1.2 choosing modes of cell entry 6.1.3 how does Nature do it? (biomimetics) …
https://nanohub.org/resources/12123
-
BME 695L Lecture 7: Assessing Zeta Potentials
03 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading. 7.1 Introduction – the importance of the zeta potential 7.1.1 nanoparticle-nanoparticle interactions 7.1.2 nanoparticle-cell interactions …
https://nanohub.org/resources/12124
-
BME 695L Lecture 8: Surface Chemistry: attaching nanomedical structures to the core
12 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading. 8.1 Introduction 8.1.1 attachment strategies typically depend on core composition 8.1.2 but the attachment strategy should not drive the …
https://nanohub.org/resources/12181
-
BME 695N Lecture 10: Nanomaterials for core design
26 Sep 2007 | Online Presentations | Contributor(s): James Leary
Outline: Introduction Core building blocks Functional cores Functionalizing the core surface Ferric oxide cores Paramagnetic cores Superparamagnetic cores Ferric nanorods Advantages and …
https://nanohub.org/resources/3313
-
BME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles
30 Sep 2007 | Online Presentations | Contributor(s): Don Bergstrom
With Donald E. Bergstrom as guest lecturer.
https://nanohub.org/resources/3331
-
BME 695N Lecture 17: Assessing nanotoxicity at the single cell level
06 Nov 2007 | Online Presentations | Contributor(s): James Leary
Outline: Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of …
https://nanohub.org/resources/3497
-
BME 695N Lecture 1: Need for New Perspectives on Medicine
03 Aug 2007 | Online Presentations | Contributor(s): James Leary
Outline: The Progression of Medicine Conventional "modern" medicine "Personalized" or "molecular" medicine Nanomedicine "single-cell" medicine How Conventional Medicine Works for Diagnosis of …
https://nanohub.org/resources/3047
-
BME 695N Lecture 20: GMP and issues of quality control manufacture of nanodelivery systems
15 Nov 2007 | Online Presentations | Contributor(s): James Leary
Outline: Overview What does cGMP mean? Why GMP? Controlling processes means more predictable outcomes… Enforcement What can be learned from the semi-conductor industry …
https://nanohub.org/resources/3529
-
BME 695N Lecture 21: FDA and EPA Regulatory Issues
27 Nov 2007 | Online Presentations | Contributor(s): James Leary
Outline: Introduction and overview How does the FDA think about nanomedical systems? The 2006 Nanotechnology Task Force Some details of the Nanotechnology Task Force Report …
https://nanohub.org/resources/3549
-
BME 695N Lecture 2: Basic Concepts of Nanomedical Systems
28 Aug 2007 | Online Presentations | Contributor(s): James Leary
Outline: Features of Nanomedicine Bottoms up rather than top down approach to medicine Nano-tools on the scale of molecules Cell-by-cell repair approach – regenerative medicine Feedback …
https://nanohub.org/resources/3095
-
BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design
29 Aug 2007 | Online Presentations | Contributor(s): James Leary
Outline: Nanomedical systems – levels of challenges Essential elements of a nanomedical system Requirements for specific cell targeting Consequences of mis-targeting Engineering around the …
https://nanohub.org/resources/3108