Tags: biomedical engineering

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  1. BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo

    26 Sep 2007 | | Contributor(s):: James Leary

    Outline:Assessing nanomedical system (NMS) targeting at the single cell levelFluorescent labeling of NMSsFirst estimates of NMS binding by fluorescence microscopyInternal of external binding by confocal microscopySingle-cell image/confocal analysisFlow cytometric quantitation of NMS binding to...

  2. BME 695N Lecture 10: Nanomaterials for core design

    26 Sep 2007 | | Contributor(s):: James Leary

    Outline:IntroductionCore building blocksFunctional coresFunctionalizing the core surfaceFerric oxide coresParamagnetic coresSuperparamagnetic coresFerric nanorodsAdvantages and disadvantagesC60 and carbon nanotubesSize and structure of C60Elongation of C60 into carbon nanotubesAdvantages and...

  3. BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells

    24 Sep 2007 | | Contributor(s):: James Leary

    Outline:Introduction to measuring technologies for nanomedical system interaction with cellsThe importance of quantitative or at least semi-quantitative single cell measurementsto detect presence and location of nanomedical systemsBelow "optical limit" imagingRequirements on the NMS to have...

  4. BME 695N Lecture 7: Normal & facilitated cell entry mechanisms

    15 Sep 2007 | | Contributor(s):: James Leary

    Outline:IntroductionThe general problem of cell entryChoosing modes of cell entryHow does Nature do it? (biomimetics)Non-specific uptake mechanismsPinocytosis by all cellsPhagocytosis by some cellsReceptor mediated uptakeReceptor mediated transport of desired moleculesExample- transferrin...

  5. BME 695N Lecture 5: Cell Targeting

    12 Sep 2007 | | Contributor(s):: James Leary

    Outline:Overview: targeting nanosystems to cellsAntibody targetingPeptide targetingAptamer targetingAntibodies – polyclonal and monoclonalWhere do antibodies come from – in nature?How do we make them in the laboratory?Monoclonal antibodiesTherapy problems with mouse monoclonal...

  6. BME 695N Lecture 4: Designing "Theragnostic" Systems

    04 Sep 2007 | | Contributor(s):: James Leary

    Outline:Bridging the gap between diagnostics and therapeuticsHow conventional medicine is practiced in terms of diagnostics and therapeuticsThe consequences of separating diagnostics and therapeuticsA new approach – "theragnostics" (or "theranostics")Examples of current theragnostic...

  7. BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design

    29 Aug 2007 | | Contributor(s):: James Leary

    Outline:Nanomedical systems – levels of challengesEssential elements of a nanomedical systemRequirements for specific cell targetingConsequences of mis-targetingEngineering around the consequences of mis-targetingSome ways to lower mis-targeting to non-diseased cells

  8. BME 695N: Engineering Nanomedical Systems (Fall 2007)

    03 Aug 2007 | | Contributor(s):: James Leary

    This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and structure...

  9. BME 695N Lecture 2: Basic Concepts of Nanomedical Systems

    28 Aug 2007 | | Contributor(s):: James Leary

    Outline: Features of NanomedicineBottoms up rather than top down approach to medicine Nano-tools on the scale of molecules Cell-by-cell repair approach – regenerative medicine Feedback control system to control drug dosing Elements of good engineering designWhenever possible, use a general...

  10. Re-engineering a Healthy Eye Tissue to Restore Damaged Eyesight

    02 Aug 2007 | | Contributor(s):: Margarita Shalaev

    Age-related macular degeneration (AMD) is an eye disease that is the leading cause of blindness in the USA and Western Europe. It affects over one million people in the United States alone. One of the symptoms of AMD is a diseased Bruch’s membrane, which is an important layer in the eye. Our...

  11. BME 695N Lecture 1: Need for New Perspectives on Medicine

    03 Aug 2007 | | Contributor(s):: James Leary

    Outline:The Progression of MedicineConventional "modern" medicine "Personalized" or "molecular" medicineNanomedicine "single-cell" medicineHow Conventional Medicine Works for Diagnosis of DiseaseIdentification of the "diseased state"Simple measurements of body structure and functionFollow-up...