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Cell Factory for Small Molecule Inducible Delivery of Low Dose IL-2
31 Aug 2023 | | Contributor(s):: Celsa Pachlhofer, Yafet Arefeayne, Rice University
Autoimmune and inflammatory diseases are characterized by insufficient regulatory T cells (Treg), which play a central role in maintaining peripheral tolerance, preventing autoimmunity, and limiting chronic inflammation. Treg cells depend on IL-2 for survival and maintenance of their...
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NanoMedicine
07 Oct 2022 | | Contributor(s):: Jared Ashcroft, NACK Network
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Your Smart Brain
21 Aug 2022 | | Contributor(s):: Rubiona Grainger, Rice University, NEWT Center
Researchers have differentiated hESCs into forebrain, midbrain and hindbrain. However, observing cell interpretation of signals to form dorsal-ventral patterning tissues with sonic hedgehog (SHH) gene is necessary. We used micropatterning within different timeframes to determine how cell fates...
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Neutral Pattering of Stem Cells
20 Aug 2022 | | Contributor(s):: Donna Booker, Rice University
How do cells pattern and establish the complex structures of the brain? How does a cell know that it will be part of the forebrain or the hindbrain? By using embryonic stem cells, this project focuses on researching how proteins and genes interact with each other to establish instructions...
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Building & Testing a Component of Synthetic Genetic Circuit in Mammalian Cells
20 Aug 2022 | | Contributor(s):: Ariel Delos Reyes, Rice University
Oscillations in protein levels within cells help facilitate a variety of biological processes, from circadian rhythm to cell cycle progression. This research focuses on developing a platform for creating oscillatory circuits in mammalian cells by using several interrelated DNA constructs....
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Nanotechnology: The Future of Medicine?
28 Jul 2022 | | Contributor(s):: Jared Ashcroft, The Micro Nano Technology - Education Center
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Got GMOs?: An EngrTEAMS Curricular Unit
20 Jun 2022 | | Contributor(s):: Jolene Chrzaszcz, Brian Eberhardt, Rob Johnson, Maurina Aranda, Selcen Guzey, Beth Ring, Kerrie Douglas, Tamara J. Moore
Got GMOs? is an engineering design-based STEM curricular unit. The unit aims to facilitate the learning of major science and mathematical concepts and skills within the Next Generation Science Standards (NGSS) and Common Core State Standards (CCSS) respectively. The unit includes teacher guides,...
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Agent Based Active Matter Simulations with Mechanica
14 Nov 2021 | | Contributor(s):: Somogyi, Andy T
Mechanica is an interactive mesh-free, chemistry and biology simulation environment, with an emphasis towards enabling users to model and simulate complex sub-cellular and cellular biological physics problems. Mechanica is designed first and foremost to enable users to work interactively...
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Winter Interactive nanoBIO Workshop
04 Feb 2021 | | Contributor(s):: Ballard, Joshua Brendan (editor)
The Winter Interactive nanoBIO Workshop will walk students and researchers through how to understand a variety of biological problems using simulations based on cloud-based tools on nanoHUB or other easy to use platforms.
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How Simple Cell-Cell Interactions Lead to Complex Multicellular Dynamics
04 Feb 2021 | | Contributor(s):: Paul Macklin
In this talk, we use agent-based simulation models to simulate (1) individual cell behaviors, (2) cell-cell interactions, and (3) cell-environment interactions to show how simple rules can give rise to complex multicellular phenomena. We showcase and explore free, interactive online tools to...
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Biology of COVID-19 Attack on Epithelial Cells, understood from a Modeling and Simulation Perspective
04 Feb 2021 | | Contributor(s):: Paul Macklin
n this session, we describe a community-driven effort to iteratively develop a multiscale, spatially-resolved open source model of SARS-CoV-2 dynamics and immune response in tissues.
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PhysiCell model for tumor hypoxia
07 Aug 2020 | | Contributor(s):: Lima Da Rocha, Heber, Paul Macklin, Furkan Kurtoglu
Multicellular simulation in 2-D of tumor hypoxia.
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CompuCell3D v4 Main Tool
08 Jun 2020 | | Contributor(s):: Juliano Ferrari Gianlupi, T.J. Sego
Base tool for CompuCell3D version 4 and greater. Allows running any of the demos included with CC3D (/CompuCell3D_Demos/Demos)
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Understanding Movement of Molecules across the Cell Membrane
17 Apr 2020 | | Contributor(s):: Brandi Childress, NNCI Nano
This lesson uses a macro-model to demonstrate the diffusion of molecules across the cell membrane. A deshelled egg serves as the cell model to observe movement in and out of the “cell”. Students will learn that the cell membrane is composed of a complex nano-structured...
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Linear Diffusion and Cell Signaling
17 Apr 2020 | | Contributor(s):: NNCI Nano
In this activity, students explore the concept of diffusion as a component of cell communication. Specifically, students will explore how the rate of diffusion varies with distance and concentration gradient. They will use a pipet with water and dye to observe a macro-model of diffusion....
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Soft Materials for Studying Hard Biological Problems
15 Oct 2019 | | Contributor(s):: Kristi S. Anseth
This talk will illustrate how we leverage these and other reversible chemistries to create biologically responsive hydrogel matrices, and employ them to study the effects of matricellular signaling on diverse cellular functions and processes. For example, we exploit...
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Replication Competent Oncolytic Virus in Epithelial cell layer
18 Apr 2019 | | Contributor(s):: Adrianne Jenner, Paul Macklin
PhysiCell simulation of a replication competent oncolytic virus release from two veins, diffusing through a layer of epithelial cells.
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CELL-MET Thrust Area 2: Nanomechanics: Mechanical Properties of Materials, Scaffolds and Cardiac Tissues
04 Apr 2019 | | Contributor(s):: Pranjal Nautiyal
In this presentation, FIU graduate student Pranjal Nautiyal explains his work on Nanomechanics in Arvind Agarwal's Lab.
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CELL-MET Thrust Area 2 - Nanomechanics: Cell-Integrated Surface Plasmon Resonance
08 Feb 2019 | | Contributor(s):: Maedeh Mozneb, CELL-MET ERC
In this presentation, FIU graduate student Maedeh Mozneb explains her work on Nanomechanics in Chen-Zhong Li’s lab.
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Cells: The Building Blocks of Life Learning Module - Instructor Guides
28 Aug 2017 | | Contributor(s):: Southwest Center for Microsystems Education (SCME)
This learning module provides a review of "cells", the smallest unit exhibiting the properties of life. It discusses how these cells are being used in bioMEMS as well as other micro and nano-sized devices. A research activity provides the opportunity to further explore how...