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MCW07 Silicon Based Nanopore Sensors for Detection of DNA Molecules
11 Sep 2007 | | Contributor(s):: Samir Iqbal, Demir Akin, Rashid Bashir
Solid-state nanopores have emerged as possible candidates for next-generation DNA sequencing devices. In this talk, we will review our recent work in development of solid-state nanopore channels that are selective towards single strand DNA (ssDNA). Nanopores functionalized with a 'probe' of...
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Modeling (Semi) Unstructured Proteins
26 Mar 2008 | | Contributor(s):: Michael Colvin
The past century has seen tremendous progress in determining the biochemical and biophysical processes that constitute life. One exciting consequence of this understanding is the possibility of developing mathematical models of biological function that are accurate and even predictive. My...
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Molecular Interferometry
26 Jun 2007 | | Contributor(s):: David D. Nolte
While single-molecule detection through fluorescence has now become common-place, there has been no analogous single-molecule capability using direct detection approaches such as interferometry. This limitation is slowly yielding to high-speed interferoemtric detection that is pushing the...
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Nanoparticles in Biology and Materials: Engineering the Interface through Synthesis
29 Jan 2007 | | Contributor(s):: Vincent Rotello
Monolayer-protected nanoparticles provide versatile tools for nanotechnology. In our research, we use these nanoparticles as building blocks for the creation of functional magnetic and electronic nanocomposite materials. Simultaneously, we are using these particles as scaffolds for biomolecular...
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New Dimension in Performance: Harnessing 3D Integration Technology
29 Nov 2007 | | Contributor(s):: Kerry Bernstein
Despite generation on generation of scaling, computer chips have remained essentially 2-dimensional. Improvements in on-chip wire delay, and in the total number of inputs and outputs has not been able to keep up with improvements to the transistor, and its getting harder and harder to hide it! 3D...
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Nucleic Acids
07 May 2007 | | Contributor(s):: Don Bergstrom
Living organisms are self-assembling systems that achieve an enormous variety of functions through organization of components from sub-nanometer to meter scale. Understanding the functions of these systems must start with a study of the molecular components, their structures and interactions. By...
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Oligodeoxyribonucleotide Association with Single-Walled Carbon Nanotubes
02 Aug 2007 | | Contributor(s):: Jennifer McDonald
Commercially available single-walled carbon nanotubes (SWCNTs) tend to aggregate as ropes and bundles during production making them of little use in many scientific and industrial applications. An effective technique for dispersing and solubilizing SWCNTs is required to fully utilize their unique...
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On the Cross Roads of Biology and Nanotechnology – Selective DNA Nanopore Sensors
21 Mar 2007 | | Contributor(s):: Samir Iqbal
The ability to manipulate and identify the properties of singlebiological molecules with the potential of characterizing biologicalprocesses at the most fundamental levels can significantly facilitaterapid diagnostics and therapeutics. Fabrication of solid-statedevices investigating bacteria,...
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Quantitative, Kinetic Models of Cellular Circuits
25 Feb 2009 | | Contributor(s):: Michael R. Brent
Living cells contain complex, analog circuits that regulate the rate at which each gene produces its product. The kinetic properties of these circuits enable cells to respond to changes in their environments and thus to survive, reproduce, and compete. For decades, molecular biologists have been...
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Sizing DNA with Artficial Nanopores
26 Jul 2004 | | Contributor(s):: Aleksei Akisimen
Sizing DNA with Artficial Nanopores
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Surface Characterization Studies of Carbon Materials: SS-DNA, SWCNT, Graphene, HOPG
30 Jan 2010 | | Contributor(s):: Dmitry Zemlyanov
In this presentation examples of surface characterization studies of carbon specimens will be presented. (1) In particularly, the systematic XPS (X-ray photoelectron spectroscopy) characterization of graphene grown on the SiC surface will be reported. This work demonstrates a use for XPS to...
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Vertically Aligned Carbon Nanotube for Interconnects and Nanoelectrode Based Biosensors
15 Apr 2004 | | Contributor(s):: Jun Li
In the past few years, tremendous progress in the growth of carbon nanotubes (CNTs) has been made, which enabled the fabrication of various CNT devices for applications in electronics, biomedical techniques, and chemical/biological sensors. We have established a process to grow vertically aligned...