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BME 695L Lecture 10: Nanodelivery of Therapeutic Genes and Molecular Biosensor Feedback Control Systems
26 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.10.1 Introduction and overview10.1.1 Some of the advantages of therapeutic genes10.1.2 Some of the advantages of molecular biosensor feedback control...
BME 695L Lecture 11: Assessing Nanotoxicity at the Single Cell Level
27 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.11.1 Need for single cell measures of nanotoxicity11.1.1 There is more than one way for a cell to die...11.1.2 "Necrosis" vs. "Apoptosis"11.1.3 There...
BME 695L Lecture 12: Assessing Drug Efficacy and Nanotoxicity at the Single Cell Level
22 Nov 2011 | | Contributor(s):: James Leary
See references below for related reading.12.1 Introduction to measures of efficacy for nanomedicine12.1.1 for evaluation purposes, does structure/size reveal function?12.1.2 nanomedical treatment at the single cell...
BME 695L Lecture 13: Designing Nanomedical Systems (NMS) for In-vivo Use
See references below for related reading.13.1 Bringing in-vivo considerations into NMS design13.1.1 the in-vitro to ex-vivo to in-vivo paradigm 220.127.116.11 In-vitro - importance of choosing...
BME 695L Lecture 14: Designing and Testing Integrated Nanomedical Systems
See references below for related reading.14.1 Introduction to integrated designs14.1.1 “Total design” but there is some order in the design process14.1.2 A brief outline of the total design...
BME 695L Lecture 15: GMP and Issues of Quality Control Manufacture of Nanodelivery Systems
02 Dec 2011 | | Contributor(s):: James Leary
See references below for related reading.15.1 Overview15.1.1 What does cGMP mean?15.1.2 Why GMP? Controlling processes means more predictable...
BME 695L Lecture 9: Challenges of Proper Drug Dosing with Nanodelivery Systems
19 Oct 2011 | | Contributor(s):: James Leary
See references below for related reading.9.1 Overview of drug dosing problem9.1.1 Problems of scaling up doses from animal systems9.1.2 Basing dosing on size, area, weight of...
BME 695L Special Lecture 3: In vivo Model Systems to Study Nanomedical Approaches to Cancer Detection and Intervention
02 Dec 2011 | | Contributor(s):: Deborah W Knapp
Guest lecturer: Deborah Knapp.
BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems
out of 5 stars
29 Oct 2007 | | Contributor(s):: James Leary
Outline:Overview of drug dosing problemProblems of scaling up doses from animal systemsBasing dosing on size, area, weight of recipientVast differences between adults in terms of genetics, metabolismDosing in children – children are NOT smaller adults!Pharmacokinetics – drug distribution,...
BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems
30 Oct 2007 | | Contributor(s):: James Leary
Outline:Introduction and overviewSome of the advantages of therapeutic genesSome of the advantages of molecular biosensor feedback control systemsWhy a nanodelivery approach is appropriateThe therapeutic gene approachWhat constitutes a "therapeutic gene" ?Transient versus stable expression...
BME 695N Lecture 16: Assessing drug efficacy at the single cell level
02 Nov 2007 | | Contributor(s):: James Leary
Outline:Introduction and overviewNanomedical treatment at the single cell level requires evaluation at the single cell levelFor evaluation purposes, does structure reveal function?The difficulty of anything but simple functional assaysThe need for assays which at least show correlation to...
BME 695N Lecture 17: Assessing nanotoxicity at the single cell level
06 Nov 2007 | | Contributor(s):: James Leary
Outline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned...
BME 695N Lecture 18: Designing nanodelivery systems for in-vivo use
12 Nov 2007 | | Contributor(s):: James Leary
Outline:Overview – the in-vitro to ex-vivo to in-vivo paradigm In-vitro - importance of choosing suitable cell lines Ex-vivo – adding the complexity of in-vivo background while keeping the simplicity of in-vitro In-vivo - all the complexity of ex-vivo plus the “active” components of a real...
BME 695N Lecture 19: In vivo model systems to study nanomedical approaches to cancer detection and intervention
27 Nov 2007 | | Contributor(s):: Deborah W Knapp
With Deborah Knapp as guest lecturer.
Design of Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery and Theragnostics
02 Jul 2008 | | Contributor(s):: James Leary
Multi-component and multifunctional nanoparticles hold great promise for drug/gene delivery and simultaneous diagnostics and therapeutics ("theragnostics"). Sophisticated multi-component systems can employ collections of specialized molecules in a nanodelivery system whose actions can be...
Development of Highly Porous Large Polymeric Microparticles for Sustained Local Drug Delivery to the Lung
10 Jul 2008 | | Contributor(s):: Yoon Yeo
In this presentation, I will introduce a new way of making highly porous large polymeric microparticles recently developed in my lab. These microparticles exhibited desirable aerodynamic properties, reduced macrophage uptake, encapsulated a drug efficiently, and provided sustained drug release...
Engineering Nanomedical Systems
16 Nov 2007 | | Contributor(s):: James Leary
This tutorial will cover general problems and approaches to the design of engineered nanomedical systems. An example to be covered is the engineering design of programmable multilayered nanoparticles (PMNP) to control a multi-sequence process of targeting to rare cells in-vivo, re-targeting to...
Functionalized Nanomaterials at the Interface of Biology and Technology
24 Apr 2008 | | Contributor(s):: Dean Ho, National Center for Learning & Teaching in Nanoscale Science & Engineering
Nanomaterials, such as block copolymeric membranes and nanodiamonds, can be engineered for a broad range of applications in energy and medicine. This presentation will highlight the relevance of these materials as foundations for device fabrication across the spectrum of biology and technology....
Illinois BioNanotechnology Seminar Series Fall 2011: Precisely Size Controlled Drug-silica Nanoconjugate for Cancer Therapy
05 Dec 2011 | | Contributor(s):: Li Tang
Drug delivery nanomedicine, exemplified by micelles and nanoparticles roughly in the size range of 1-200 nm, have attracted much interest in the past 2-3 decades as alternative modalities for cancer treatment. The size of these drug delivery vehicles has been strongly correlated with their in...
KIST/PU A bi-functional block copolymer hydrogels and micelles for protein and drug delivery
28 Nov 2007 | | Contributor(s):: Doo Sung Lee
Novel biodegradable & injectable poly(Î²-amino ester)-poly(Îµ-caprolactone)-poly(ethylene glycol)-poly(Îµ-caprolactone)-poly(Î²-amino ester)(PAE-PCL-PEG-PCL-PAE) bi-functional, pH/temperature-sensitive, block copolymer hydrogels were prepared and applied to protein and drug delivery. In this...