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Functionalized Nanomaterials at the Interface of Biology and Technology
out of 5 stars
24 Apr 2008 | | Contributor(s):: Dean Ho, National Center for Learning & Teaching in Nanosca
Nanomaterials, such as block copolymeric membranes and nanodiamonds, can be engineered for a broad range of applications in energy and medicine. This presentation will highlight the relevance of these materials as foundations for device fabrication across the spectrum of biology and technology....
KIST/PU A bi-functional block copolymer hydrogels and micelles for protein and drug delivery
28 Nov 2007 | | Contributor(s):: Doo Sung Lee
Novel biodegradable & injectable poly(Î²-amino ester)-poly(Îµ-caprolactone)-poly(ethylene glycol)-poly(Îµ-caprolactone)-poly(Î²-amino ester)(PAE-PCL-PEG-PCL-PAE) bi-functional, pH/temperature-sensitive, block copolymer hydrogels were prepared and applied to protein and drug delivery. In this...
BME 695N Lecture 19: In vivo model systems to study nanomedical approaches to cancer detection and intervention
27 Nov 2007 | | Contributor(s):: Deborah W Knapp
With Deborah Knapp as guest lecturer.
Engineering Nanomedical Systems
16 Nov 2007 | | Contributor(s):: James Leary
This tutorial will cover general problems and approaches to the design of engineered nanomedical systems. An example to be covered is the engineering design of programmable multilayered nanoparticles (PMNP) to control a multi-sequence process of targeting to rare cells in-vivo, re-targeting to...
BME 695N Lecture 18: Designing nanodelivery systems for in-vivo use
12 Nov 2007 | | Contributor(s):: James Leary
Outline:Overview – the in-vitro to ex-vivo to in-vivo paradigm In-vitro - importance of choosing suitable cell lines Ex-vivo – adding the complexity of in-vivo background while keeping the simplicity of in-vitro In-vivo - all the complexity of ex-vivo plus the “active” components of a real...
BME 695N Lecture 17: Assessing nanotoxicity at the single cell level
06 Nov 2007 | | Contributor(s):: James Leary
Outline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned...
BME 695N Lecture 16: Assessing drug efficacy at the single cell level
02 Nov 2007 | | Contributor(s):: James Leary
Outline:Introduction and overviewNanomedical treatment at the single cell level requires evaluation at the single cell levelFor evaluation purposes, does structure reveal function?The difficulty of anything but simple functional assaysThe need for assays which at least show correlation to...
BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems
30 Oct 2007 | | Contributor(s):: James Leary
Outline:Introduction and overviewSome of the advantages of therapeutic genesSome of the advantages of molecular biosensor feedback control systemsWhy a nanodelivery approach is appropriateThe therapeutic gene approachWhat constitutes a "therapeutic gene" ?Transient versus stable expression...
BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems
29 Oct 2007 | | Contributor(s):: James Leary
Outline:Overview of drug dosing problemProblems of scaling up doses from animal systemsBasing dosing on size, area, weight of recipientVast differences between adults in terms of genetics, metabolismDosing in children – children are NOT smaller adults!Pharmacokinetics – drug distribution,...
KIST/PU Bridging Nonlinear Optical Imaging and Nanotechnology with Medicine
23 Oct 2007 | | Contributor(s):: Ji-Xin Cheng
Our interdisciplinary research develops and utilizes state-of-the-art optical imaging techniques and nanotechnology to tackle compelling biomedical problems highly related to human health. Research in my group covers diagnosis, treatment, and mechanistic study of diseases.
KIST/PU Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery
23 Oct 2007 | | Contributor(s):: James Leary
In this brief paper we describe some of our recent efforts to construct multi-component, multi-functional nanomedical systems for delivery of therapeutic genes. We first describe the general philosophy of our approach. Then we describe three specific aspects of the overall construction in simple...
KIST/PU Tumor-Homing Chitosan-Based Nanoparticles for Cancer Theragnosis; Imaging, Drug Delivery and Therapy
23 Oct 2007 | | Contributor(s):: Ick Chan Kwon
We have prepared self-assembled polymeric drug carriers containing fluorophore and loaded drugs for theragnostic imaging of tumors. This new type of polymeric drug carriers visualizes the accumulation of carriers at tumor sites, and evaluates therapeutic efficacies, and thereby providing an...
KIST/PU 2nd Annual Symposium: Molecular Imaging and Theragnosis
23 Oct 2007 |
This symposium presents an overview of the research of the Global Research Laboratory (GRL), a program that reflects a direct collaboration of scientific research between South Korea (Korea Institute of Science and Technology [KIST] and its affiliated research institutions) and the United States...
BME 695N: Engineering Nanomedical Systems (Fall 2007)
03 Aug 2007 | | Contributor(s):: James Leary
This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and structure...
Polymers for nanoparticle and nanocrystal formulations for drug delivery
15 May 2007 | | Contributor(s):: Stephen R. Byrn
Nanoparticles hold great promise for drug delivery applications. Nanoparticles might prove to be the only way to bring water insoluble, chemically unstable drugs to market. Because of this, this seminar will summarize the use of polymers to prepare and/or coat nanoparticles. Preliminary studies...
Nanotechnologies, Science and Society: Promises and Challenges
10 May 2007 | | Contributor(s):: James Leary