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Illinois BIOE 498 BioNanotechnology and Nanomedicine: Applications in Cancer and Mechanobiology
26 Oct 2011 | | Contributor(s):: Rashid Bashir, Taher A. Saif, Ann M Nardulli, Catherine J. Murphy
BioNanotechnology and Nanomedicine: Applications in Cancer and Mechanobiology will provide an introduction to basic concepts of nanotechnology in mechanobiology and in cancer. This is a highly interdisciplinary field of research where knowledge from various disciplines will be presented and...
Illinois BioNanotechnology Seminar Series Fall 2011: Deconvolving Stiffness in MEMS Pedestal Cell Mass Measurements
05 Dec 2011 | | Contributor(s):: Elise Corbin
The complex relationships between a cell's behavior and the physical properties of both itself and its environment have long been of interest. Specifically, the understanding the mechanisms through which a cell's physical properties influence cell growth, cell differentiation, cell cycle...
Illinois BioNanotechnology Seminar Series Fall 2011: Directed Blood Vessel Growth Using an Angiogenic Microfiber/Microparticle Composite Patch
05 Dec 2011 | | Contributor(s):: Ross J DeVolder
Therapeutic angiogenesis has emerged as a promising strategy to treat various acute and chronic vascular diseases, and to enhance tissue repair and regeneration. Common revascularization therapies include the administration of angiogenic factors, such as vascular endothelial growth factor...
Illinois BioNanotechnology Seminar Series Fall 2011: In vitro Cancer Metastasis Driven by Elasticity of Micro-environment
27 Oct 2011 | | Contributor(s):: Xin Tang
Cancer deaths are primarily caused by metastases, not by the parent tumor. However, the physical-chemical mechanisms and parameters within the cellular micro-environment that initiate the onset of metastasis, are not understood. Here we show that human colon carcinoma (HCT-8) cells can exhibit a...
Illinois BioNanotechnology Seminar Series Fall 2011: Investigating Dendritic Filopodial Dynamics in Highly Controlled Microenvironments
21 Jan 2012 | | Contributor(s):: Anika Jain
The establishment of the intricate wiring of the nervous system relies on filopodial navigation to form complex interconnections between neurons. Until recently, cellular level investigations into filopodial dynamics had focused primarily on axonal growth cone filopodia. Here we focus on their...
Illinois BioNanotechnology Seminar Series Fall 2011: Magnetomotive Molecular Nanoprobe
27 Oct 2011 | | Contributor(s):: Stephen Boppart
The diagnostic, interrogational, and therapeutic potential of molecular nanoprobes is rapidly being investigated and exploited across virtually every biomedical imaging modality. While many types of probes enhance contrast or delivery therapy by static localization to targeted sites, significant...
Illinois BioNanotechnology Seminar Series Fall 2011: Mechanotransduction at Cell-Cell Contact
04 Apr 2012 | | Contributor(s):: Hamid Tabdili
Differential adhesion between cadherin subtypes expressed on cell surfaces is postulated to direct cell segregation during tissue morphogenesis. The studies described here used magnetic twisting cytometry and traction force microscopy to test the impact of cadherin binding selectivity on...
Illinois BioNanotechnology Seminar Series Fall 2011: Multi-Modal and Multi-Functional Magnetic Particles for Cancer Imaging
27 Oct 2011 | | Contributor(s):: Adeel Ahmad
Illinois BioNanotechnology Seminar Series Fall 2011: Precisely Size Controlled Drug-silica Nanoconjugate for Cancer Therapy
05 Dec 2011 | | Contributor(s):: Li Tang
Drug delivery nanomedicine, exemplified by micelles and nanoparticles roughly in the size range of 1-200 nm, have attracted much interest in the past 2-3 decades as alternative modalities for cancer treatment. The size of these drug delivery vehicles has been strongly correlated with their in...
Illinois BioNanotechnology Seminar Series Spring 2011: Development of Anticancer Medicine
14 Apr 2011 | | Contributor(s):: Jianjun Cheng
Nanoparticles are promising carriers for the delivery of chemotherapeutics for cancer therapy. This presentation explores new developments in chemical and engineering processes to prepare anticancer nanomedicines.
Illinois BioNanotechnology Seminar Series Spring 2011: Engineering Cellular Microenvironments for Biomedicine
14 Apr 2011 | | Contributor(s):: Brendan Harley
The extracellular matrix (ECM) is a complex organization of structural proteins such as collagens and proteoglycans. Heterogeneous tissues with spatially and temporally modulated properties and their biomaterial mimics play an important role in organism physiology and regenerative medicine. With...
[Illinois] BioNanotechnology Seminar Series Fall 2011: Bio-inspired Microenvironments Regulate Cell Fate
14 Jun 2013 | | Contributor(s):: Adam Engler
Epigenetic regulation of stem cell fate by intrinsic properties of the surrounding extracellular matrix (ECM), e.g. stiffness, organization, composition, etc., appears to be an important yet underappreciated contributor in development, disease, and aging. I will describe our efforts to develop...
[Illinois] BioNanotechnology Seminar Series Fall 2011: Pluripotency and Directed Differentiation of Human Pluripotent Stem Cells
14 Jun 2013 | | Contributor(s):: Fei Wang
Our long-term goal is to define new conditions and molecular programs that govern fate decisions of human pluripotent stem cells such as human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). The knowledge is essential if we are ultimately to use these cells for...
[Illinois] Bionanotechnology Seminar Series Fall 2012: The value of an international research experience and how it can change your approach to research
26 Nov 2012 | | Contributor(s):: Heather Huntsman, Samantha Knoll
Oct. 9, 2012Heather and Samantha spent part of Summer 2012 at the Max Planck Institute in Germany.This series is organized by PhD students who are appointed as Trainees in the NIH/NCI Midwest Cancer Nanotechnology Training Center (M-CNTC) and in the NSF IGERT in Cellular and Molecular Mechanics...
[Illinois] BioNanotechnology Seminar Series Spring 2012: Dynamics of Multimodal Magnetomotive Microspheres
15 Jun 2013 | | Contributor(s):: Adeel Ahmad
Iron oxide magnetic nanoparticles (MNP's), due to their small size, unique magnetic properties and the ability to manipulate these remotely, are promising materials for diagnostic, imaging, and therapeutics in biomedical applications. In this presentation, we describe the fabrication,...
[Illinois] BioNanotechnology Seminar Series Spring 2012: Multilayered Metal Dielectric nanoLAMPS for Highly Sensitive Multiplexed Detection of Pre-metastatic Cancer Cells
15 Jun 2013 | | Contributor(s):: Sean Sivapalan
We fabricate a new class of nanoLAMPS based on recent theoretical designs by the Bhargava group. A variety of methods are adapted to create alternating metal and dielectric layered nanoparticles with embedded Raman reporter molecules. These reporter molecules are then subject to the intense...
[Illinois] BioNanotechnology Summer Institute 2014
01 Aug 2014 | | Contributor(s):: NanoBio Node
Attendees participate in two weeks of lectures and hands-on training in engineering and physical science laboratory techniques by experts in the field. Topics include cancer nanotechnology, cell mechanics, molecular biology, micro fabrication, and NanoBio devices.Featuring invited...
[Illinois] CMMB IGERT & M-CNTC Annual Symposium: A Microfluidics Approach to Probing Neuronal Filopodia
06 Jun 2013 | | Contributor(s):: Anika Jain
In her research Anika exploits the unique properties of polydimethylsiloxane (PDMS) microfluidic devices to study early neuronal development. Her group recently demonstrated the efficacy of solvent-extraction as a PDMS-treatment protocol, enabling low-density cultures of primary hippocampal...
[Illinois] CMMB IGERT & M-CNTC Annual Symposium: Detection of Mass, Growth Rate, and Stiffness of Single Adherent Cells
06 Jun 2013 | | Contributor(s):: Elise Corbin
Recently, improved MEMS resonator sensors were developed at Illinois. These can be used to directly measure the biophysical properties, mass, and growth rate of single adherent cells. Decoupling the relationship between the cell's dynamics and the apparent mass reported by the sensor is vital....
[Illinois] CMMB IGERT & M-CNTC Annual Symposium: Development of Monodisperse, Anticancer Silica-Drug Nanoconjugates
06 Jun 2013 | | Contributor(s):: Li Tang
An abstract of Li Tang's work:The goal of my Ph. D. research is to develop a precisely size-controlled drug conjugated silica nanoparticles as a new type of drug delivery system for improved cancer therapy. By using such monodisperse, drug-containing NPs with discrete and incremental difference...