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[Illinois] Extracellular Matrix Remodeling during Cancer Progression and Metastasis
09 Oct 2014 | Contributor(s):: Manu Platt
[Illinois] CMMB IGERT & M-CNTC Annual Symposium: Cell Mechanosensitivity and Metastasis
06 Jun 2013 | | Contributor(s):: Xin Tang
Human colon carcinoma (HCT-8) cells show a stable transition from low to high metastatic state when cultured on appropriately soft substrates (21 kPa). Initially epithelial (E) in nature, the HCT-8 cells become rounded (R) after seven days of culture on soft substrate. R cells show a number of...
[Illinois] Cancer Community Symposium 2012: T Cell Receptors For Potential Cancer Immunotherapy Applications: Single Chain T Cell Receptors Circumvent Mispairing with Endogenous TCR and Mediate T Cell Activity
09 May 2012 | | Contributor(s):: David H. Aggen
To improve the immune response to cancer, gene therapy with tumor-specific T cell-receptors (TCRs) provides an attractive approach to effectively arm patients T cells for tumor cell destruction. A high-affinity TCR specific for an antigenic peptide-major histocompatibility complex (pepMHC) can...