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Quality by Design and Process Analytical Technology for Pharmaceutical Manufacturing in the 21st Century
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21 Jul 2008 | | Contributor(s):: Stephen R. Byrn
PAT or Process Analytical Technology is an initiative and guidance from the U.S. FDA to encourage modernization of pharmaceutical manufacturing. In reality, PAT is a subset of the larger concept of Quality by Design which is the implementation of design concepts for pharmaceutical dosage forms...
Strategies for Preparation and Manufacture of Polymer-based Nanoparticulate Formulations
Nanoparticles hold great promise for drug delivery applications. Several polymer-based formulations containing nanoparticles are in late phase development or on the market. In fact, polymer dispersions provide one of the best methods to prepare nanoparticles of small-molecule organic drugs....
Multiplex Detection of Cell Surface Markers using Plasmonic Sensors
21 Jul 2008 | | Contributor(s):: Joseph M K Irudayaraj
Gold nanorod molecular probes (GNrMPs) were designed and fabricated for multiplex identification of cell surface markers in HBECs. Cells were probed directly using dark field microscopy integrated with a spectral imager for simultaneous detection of up to three surface markers. The...
Discovery Park at Purdue University: Engine for Academic and Commercial Growth
10 Jul 2008 | | Contributor(s):: Charles Buck, Pankaj Sharma
The Bindley Bioscience Center and Birck Nanotechnology Center at Discovery Park blend life sciences and engineering research to cultivate and support innovative, multi-investigator, interdisciplinary research teams. Discovery Park engages researchers in a broader perspective with applications of...
Design of Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery and Theragnostics
02 Jul 2008 | | Contributor(s):: James Leary
Multi-component and multifunctional nanoparticles hold great promise for drug/gene delivery and simultaneous diagnostics and therapeutics ("theragnostics"). Sophisticated multi-component systems can employ collections of specialized molecules in a nanodelivery system whose actions can be...
High-Aspect-Ratio Micromachining of Titanium: Enabling New Functionality and Opportunity in Micromechanical Systems Through Greater Materials Selection
18 Jun 2008 | | Contributor(s):: Masa Rao
Traditionally, materials selection has been limited in high-aspect-ratio micromechanical applications, due primarily to the predominance of microfabrication processes and infrastructure dedicated to silicon. While silicon has proven to be an excellent material for many of these applications, no...
Ionic Selectivity in Channels: complex biology created by the balance of simple physics
05 Jun 2008 | | Contributor(s):: Bob Eisenberg
An important class of biological molecules—proteins called ionic channels—conduct ions (like Na+ , K+ , Ca2+ , and Cl− ) through a narrow tunnel of fixed charge (‘doping’). Ionic channels control the movement of electric charge and current across biological membranes and so play a role in...
BNC Research Review: Carbon Nanotubes as Nucleic Acid Carriers
04 Jun 2008 | | Contributor(s)::
This presentation is part of a collection of presentations describing the projects, people, and capabilities enhanced by research performed in the Birck Center, and a look at plans for the upcoming year.
BNC Research Review: The Birck Nanotechnology Center-Progress, Opportunitiees, and Challenges
Nano Carbon: From ballistic transistors to atomic drumheads
14 May 2008 | | Contributor(s):: Paul L. McEuen
Carbon takes many forms, from precious diamonds to lowly graphite. Surprisingly, it is the latter that is the most prized by nano physicists. Graphene, a single layer of graphite, can serve as an impenetrable membrane a single atom thick. Rolled up into a nanometer-diameter cylinder--a carbon...
Bionanotechnology: a different perspective
30 Apr 2008 | | Contributor(s):: Murali Sastry
The study of the synthesis, exotic properties, assembly/packaging and potential commercial application of nanomaterials is an extremely important topic of research that is expected to have far-reaching global impact. The focus of my talk will be on an emerging branch of nanotechnology that...
Functionalized Nanomaterials at the Interface of Biology and Technology
24 Apr 2008 | | Contributor(s):: Dean Ho, National Center for Learning & Teaching in Nanosca
Nanomaterials, such as block copolymeric membranes and nanodiamonds, can be engineered for a broad range of applications in energy and medicine. This presentation will highlight the relevance of these materials as foundations for device fabrication across the spectrum of biology and technology....
Lecture 6: Magnetic Tweezers
07 Apr 2008 | | Contributor(s):: Paul R Selvin
Introduction II and Applications
Nanotechnologies and Medical Ethics
02 Apr 2008 | | Contributor(s):: Nigel M. de S. Cameron
Using Mass Spectrometry to Understand Membrane Organization
28 Mar 2008 | | Contributor(s):: Mary Kraft
Our ability to engineer tissues and biomimetic devices hinges upon an understanding of the structure-function relationship in healthy and diseased cells. Our laboratory utilizes materials characterization, quantitative engineering principles, cell biology and chemistry to elucidate the influence...
Modeling (Semi) Unstructured Proteins
26 Mar 2008 | | Contributor(s):: Michael Colvin
The past century has seen tremendous progress in determining the biochemical and biophysical processes that constitute life. One exciting consequence of this understanding is the possibility of developing mathematical models of biological function that are accurate and even predictive. My...
Nanomedicine for Treating Organ Failure
02 Jan 2008 | | Contributor(s)::
Nanotechnology has begun to revolutionize numerous science and engineering fields. The use of nanotechnology in medicine has been termed nanomedicine. This presentation will highlight recent advancements in the treating of organ failures (such as orthopedic, vascular, cartilage, central and...
KIST/PU Infrared and Raman Chemical Imaging of Pharmaceutical Biological Matter
06 Dec 2007 | | Contributor(s):: Tom Tague
There have been several advances in instrumentation that now facilitate infrared and Raman imaging. Current Focal-Plane-Array (FPA) detectors are very robust and read out quickly for infrared imaging and fast CCD array detectors are now available for Raman imaging. For example, infrared data...
KIST/PU Ligand-functionalized gold nanorods as theragnostic agents
06 Dec 2007 | | Contributor(s):: Alexander Wei
Plasmon-resonant gold nanorods have been examined as multifunctional agents for imaging and photoactivated therapies. Nanorods can be imaged with single-particle sensitivity by two-photon luminescence (TPL) when excited by fs-pulsed laser irradiation, and have been monitored in vivo while...
New Dimension in Performance: Harnessing 3D Integration Technology
29 Nov 2007 | | Contributor(s):: Kerry Bernstein
Despite generation on generation of scaling, computer chips have remained essentially 2-dimensional. Improvements in on-chip wire delay, and in the total number of inputs and outputs has not been able to keep up with improvements to the transistor, and its getting harder and harder to hide it!...