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Engineering Nanomedical Systems
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16 Nov 2007 | | Contributor(s):: James Leary
This tutorial will cover general problems and approaches to the design of engineered nanomedical systems. An example to be covered is the engineering design of programmable multilayered nanoparticles (PMNP) to control a multi-sequence process of targeting to rare cells in-vivo, re-targeting to...
MCW07 Impact of Porphyrin Functional Groups on InAs Gas Sensors
05 Nov 2007 | | Contributor(s):: Michael Garcia
Porphyrin molecules are often used for sensor engineering to improve sensitivity and selectivity to specific analytes. It is important to understand how the porphyrin HOMO-LUMO levels deplete surface states during functionalization of solid state sensors. Additionally, the effect of...
KIST/PU Multiplex Detection of Cell Surface Markers Using Plasmonic Sensors
23 Oct 2007 | | Contributor(s):: Joseph M K Irudayaraj
Gold nanorod molecular probes (GNrMPs) were designed and fabricated for multiplex identification of cell surface markers in HBECs. Cells were probed directly using dark field microscopy integrated with a spectral imager for simultaneous detection of up to three surface markers. The...
KIST/PU Design and Performance of Bioresponsive Nanocarriers with Tunable Reactivity for Drug and Gene Delivery
23 Oct 2007 | | Contributor(s):: Dave Thompson
Our lab has focused on the development of bioresponsive nanocarriers that are designed to release their cargo upon entry into acidic environments such as those found in cellular endosomes and sites of poor circulation. Computational methods have been used to design vinyl ether lipids of varying...
KIST/PU Introduction to Global Research Laboratory (GRL) Program: Molecular Imaging and Nanomedicine for Theragnosis using Nano-Bio Materials
23 Oct 2007 | | Contributor(s):: Kui Won Choi
The Global Research Laboratory (GRL) program was initiated by the Korea Foundation for International Cooperation of Science and Technology (KICOS) in 2006. The GRL program has been designed to develop fundamental and original technologies through international collaborative research between...
Computing the Horribleness of Soft Condensed Matter
19 Oct 2007 | | Contributor(s):: Eric Jakobsson
A great triumph of computer simulations 40 years ago was to make the liquid state of matter understandable in terms of physical interactions between individual molecules. Prior to the first simulations of liquid argon and liquid water in the 1960's, there was no quantitatively rigorous molecular...
BME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles
30 Sep 2007 | | Contributor(s)::
With Donald E. Bergstrom as guest lecturer.
Renewable Energy from Synthetic Biology
25 Sep 2007 | | Contributor(s):: Jay D. Keasling
Jay Keasling, Co-Leader of The Helios Project, is the Director of the Physical Biosciences Division at Berkeley Lab, and a groundbreaking researcher in the new scientific field of synthetic biology. He is a UC Berkeley professor of Chemical and Bioengineering, and founder of Amyris...
MCW07 Silicon Based Nanopore Sensors for Detection of DNA Molecules
11 Sep 2007 | | Contributor(s):: Samir Iqbal, Demir Akin, Rashid Bashir
Solid-state nanopores have emerged as possible candidates for next-generation DNA sequencing devices. In this talk, we will review our recent work in development of solid-state nanopore channels that are selective towards single strand DNA (ssDNA). Nanopores functionalized with a 'probe' of...
Micro-scaled Biochips with Optically Active Surfaces for Near and Far-field Analysis of Cellular Fluorescence
31 Aug 2007 | | Contributor(s):: Huw Summers
The integration of thin (< 100 nm) metal films with micro-scaleoptical waveguides provides a route to controlled spatialexcitation of cellular fluorescence within a biochip platform.Surface bound electron-plasma oscillations (surface plasmon waves)interact with photons to produce an...
Oligodeoxyribonucleotide Association with Single-Walled Carbon Nanotubes
02 Aug 2007 | | Contributor(s):: Jennifer McDonald
Commercially available single-walled carbon nanotubes (SWCNTs) tend to aggregate as ropes and bundles during production making them of little use in many scientific and industrial applications. An effective technique for dispersing and solubilizing SWCNTs is required to fully utilize their...
Re-engineering a Healthy Eye Tissue to Restore Damaged Eyesight
02 Aug 2007 | | Contributor(s):: Margarita Shalaev
Age-related macular degeneration (AMD) is an eye disease that is the leading cause of blindness in the USA and Western Europe. It affects over one million people in the United States alone. One of the symptoms of AMD is a diseased Bruch’s membrane, which is an important layer in the eye. Our...
Biosensing applications of Plasmon Resonance in gold nanoparticles
02 Aug 2007 | | Contributor(s):: Karina Moore
Light can be used to excite plasmon resonance in gold nanoparticles. Plasmon resonance occurs on the nanoscale as the particles become excited and plasmon oscillations arise in each particle of a pair of metal nanoparticles. There is plasmon coupling between the neighboring particles as the...
26 Jun 2007 | | Contributor(s):: David D. Nolte
While single-molecule detection through fluorescence has now become common-place, there has been no analogous single-molecule capability using direct detection approaches such as interferometry. This limitation is slowly yielding to high-speed interferoemtric detection that is pushing the...
On the Cross Roads of Biology and Nanotechnology – Selective DNA Nanopore Sensors
21 Mar 2007 | | Contributor(s):: Samir Iqbal
The ability to manipulate and identify the properties of singlebiological molecules with the potential of characterizing biologicalprocesses at the most fundamental levels can significantly facilitaterapid diagnostics and therapeutics. Fabrication of solid-statedevices investigating bacteria,...
Charge Transfer Across an Energy Transducing Integral Membrane Protein Complex
31 May 2007 | | Contributor(s):: William A. Cramer
The cytochrome bc complexes of the mitochondrial respiratory and photosynthetic electron transport chains are hetero-oligomeric integral membrane proteins. These proteins are responsible for most of the energy transduction and transport activities across biological membranes. Such complexes...
Nanotechnology: Considerations for Facility Design
21 May 2007 | | Contributor(s):: John Weaver
The growing area of study broadly termed nanotechnology provides a new set of challenges to the facility designer. While evolutionary changes in the quality of clean spaces occur, it is the collaborative nature of this field that requires revolutionary changes in facility design. The main...
From Research to Learning in Chemistry through Visualization and Computation
17 May 2007 | | Contributor(s):: Eric Jakobsson
Modern chemistry research and high school chemistry education are separated by institutional and geographical boundaries. As such, much of secondary chemistry education is still based on the periodic table instead of the computational methods that drive current chemistry research. In this talk,...
Nanotechnologies, Science and Society: Promises and Challenges
10 May 2007 | | Contributor(s):: James Leary
07 May 2007 | | Contributor(s)::
Living organisms are self-assembling systems that achieve an enormous variety of functions through organization of components from sub-nanometer to meter scale. Understanding the functions of these systems must start with a study of the molecular components, their structures and interactions. By...