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BNC Annual Research Symposium: Bio-Nanotechnology and Biomedical Devices
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23 Apr 2007 | | Contributor(s):: Rashid Bashir
This presentation is part of a collection of presentations describing the projects, people, and capabilities enhanced by research performed in the Birck Center, and a look at plans for the upcoming year.
High-Aspect-Ratio Micromachining of Titanium: Enabling New Functionality and Opportunity in Micromechanical Systems Through Greater Materials Selection
09 Apr 2007 | | Contributor(s):: Masa Rao
Traditionally, materials selection has been limited in high-aspect-ratio micromechanical applications, due primarily to the predominance of microfabrication processes and infrastructure dedicated to silicon. While silicon has proven to be an excellent material for many of these applications, no...
The Impact of Protein Flexibility on Ligand Binding to Proteins: A Computational Perspective
22 Mar 2007 | | Contributor(s):: Markus A. Lill
Nowadays, computer-aided drug discovery (CADD) concepts are routinely used in academia and industry for identifying and optimizing lead structures. While CADD techniques have been widely used to attain a qualitative understanding of ligand binding to proteins, a current challenge is to quantify...
Computer Simulation of Nanoparticles, Viruses, and Electrical Power-Generating Bacteria
20 Mar 2007 | | Contributor(s)::
Models of cells and nanometer-scale biosystems are presented that clarify their physico-chemical characteristics and allow for computer- aided design of therapeutic and nanotechnical devices. Multiscale techniques are used to obtain rigorous, coarse-grained equations for the migration and...
Antiestrogenic Conjugates as New Breast Cancer Chemoprevention Agents
08 Mar 2007 | | Contributor(s):: Ross Weatherman
Tamoxifen is the first drug specifically approved for the prevention of cancer and arguably the most successful anticancer drug of all time. Although millions of breast cancer patients have benefited from tamoxifen therapy, there are side effects that hinder the broad use of tamoxifen as a...
Introduction to X-ray Photoelectron Spectroscopy and XPS Application for Biologically Related Objects
14 Feb 2007 | | Contributor(s):: Dmitry Zemlyanov
X-ray Photoelectron Spectroscopy (XPS), which is known as Electron Spectroscopy for Chemical Analysis (ESCA), is a powerful research tool for the study of the surface of solids. The technique becomes widely used for studies of the properties of atoms, molecules, solids, and surfaces. The main...
Dendrimer-Templated Catalyst for Controlled Growth of Single-Wall Carbon Nanotubes by Plasma-Enhanced CVD
20 Feb 2007 | | Contributor(s):: Placidus Amama
Carbon nanotubes (CNTs) are an important class of materials with several technological applications because they possess unparalleled properties in terms of ballistic electrical conductivity, thermal conductivity, tensile strength, and sensitivity to chemical and biological agents. To exploit...
Nanoparticles in Biology and Materials: Engineering the Interface through Synthesis
29 Jan 2007 | | Contributor(s)::
Monolayer-protected nanoparticles provide versatile tools for nanotechnology. In our research, we use these nanoparticles as building blocks for the creation of functional magnetic and electronic nanocomposite materials. Simultaneously, we are using these particles as scaffolds for biomolecular...
On Modeling Metabolic Systems
04 Jan 2007 | | Contributor(s):: Doraiswami Ramkrishna
Modeling metabolism has been generally based on the numerouscellular reactions to be in steady state with respect to theexternal fluxes on the cell boundary. The essence of this"steady state" approach is the identification of all thereaction rates (fluxes), both external and internal to the...
Plasmon-resonant Nanorods as Multifunctional Imaging Agents
28 Dec 2006 | | Contributor(s):: Alexander Wei
Gold nanorods have several outstanding characteristics as optical contrastagents for biomedical imaging. Their strong optical absorption atnear-infrared (NIR) frequencies can be used to generate contrast for opticalcoherence tomography (OCT) imaging, and is well matched for detectionmodalities...
Geometry of Diffusion and the Performance Limits of Nanobiosensors
05 Dec 2006 | | Contributor(s):: Muhammad A. Alam, Pradeep Ramachandran Nair
This presentation demonstrates how the classical diffusion-capture (D-C) model has improved sensor performance, since the D-C model is a "geometry of diffusion" rather than a "geometry of electrostatics." A scaling law based on D-C is also posited; the scaling law resolves many classical puzzles...
Potassium Channels: Conduction, Selectivity, Blockage, Inactivation, and Gating
03 Nov 2006 | | Contributor(s):: Benoit Roux, NCN at Northwestern University
The determination of the structure of the KcsA K+ channel fromStreptomyces lividan has made it possible to investigate the functionof a biological channel at the atomic level. Because of its structuralsimilarity with eukaryotic K-channels, investigations of KcsA areexpected to help understand a...
Information Theory and Cell/Nanoparticle Modeling
03 Mar 2005 | | Contributor(s)::
Physico-chemical models of cells and nanoparticles are being developed for pure and applied studies. Nanoparticles are simulated by a Poisson-Boltzmann equation (for determining the electric force field in bioelectrolyte media) while an all atom-simulator is used to determine structure. Both...
Three-Dimensional Simulations of Field Effect Sensors for DNA Detection
03 Aug 2006 | | Contributor(s):: Eddie Howell, Gerhard Klimeck
Here, the development of a DNA field-effect transistor (DNAFET) simulator is described. In DNAFETs the gate structure of a silicon on insulator (SOI) field-effect transistor is replaced by a layer of immobilized single-stranded DNA molecules which act as surface probe molecules. When...
Chemical Modification of GaAs with TAT Peptide and Alkylthiol Self-Assembled Monolayers
03 Aug 2006 | | Contributor(s):: Hamsa Jaganathan
The use of self-assembled monolayers (SAM) on semiconductors creates a basis for the design and creation of bioelectronics, such as biosensors. The interface between the surface and an organic monolayer can change significant electrical and physiochemical properties of a biological device....
Technique for High Spatial Resolution, Focused Electrical Stimulation for Electrically Excitable Tissue
08 Aug 2006 | | Contributor(s):: Matteo Mannino
Cochlear implant devices have made use of electrode pulses as a method of nerve fiber stimulation since their early conception. Electrode stimulation is limiting in both quality and consistency, and a new method is required if significant improvements to implant devices are to be made. By using...
06 Aug 2006 | | Contributor(s):: Margarita Shalaev
DNA is a relatively inexpensive and ubiquitous material that can be used as a scaffold for constructing nanowires. Our research focuses on the manufacturing of DNA-templated, magnetic nanowires. This is accomplished by synthesizing positively-charged metal nanoparticles that self-assemble along...
Surface Analysis of Organic Monlayers Using FTIR and XPS
02 Aug 2006 | | Contributor(s):: Jamie Nipple, Michael Toole, David Janes
Current research concerning self-assembled monolayers (SAM) focuses on the fabrication of microelectronics utilizing a semiconductor/molecule/metal junction. This study seeks to investigate various experimental techniques for creation of organic monolayers by surface analysis techniques...
Nanotubes and Nanowires: One-dimensional Materials
17 Jul 2006 | | Contributor(s)::
What is a nanowire? What is a nanotube? Why are they interesting and what are their potential applications? How are they made? This presentation is intended to begin to answer these questions while introducing some fundamental concepts such as wave-particle duality, quantum confinement, the...
Vector Free Energy Calculation with Adaptive Biasing Force
18 Jun 2006 | | Contributor(s):: Eric F Darve
This presentation discusses recent numerical methods to calculate thefree energy as a function of a reaction coordinate for bio-molecules.Free energy is often called potential of mean force and represents theeffective potential experienced by a generalized coordinate for abio-molecular system....