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Multianalyte Approaches to Cancer Diagnosis
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16 Aug 2005 |
Atomic Force Microscopy
01 Dec 2005 | | Contributor(s):: Arvind Raman
Atomic Force Microscopy (AFM) is an indispensible tool in nano science for the fabrication, metrology, manipulation, and property characterization of nanostructures. This tutorial reviews some of the physics of the interaction forces between the nanoscale tip and sample, the dynamics of the...
2005 Oncological Sciences Center Symposium
Progress and Problems inCancer Treatment and Prevention
First Principles-based Atomistic and Mesoscale Modeling of Materials
01 Dec 2005 | | Contributor(s):: Alejandro Strachan
This tutorial will describe some of the most powerful and widely used techniques for materials modeling including i) first principles quantum mechanics (QM), ii) large-scale molecular dynamics (MD) simulations and iii) mesoscale modeling, together with the strategies to bridge between them....
Nanoparticle Synthesis and Assembly for Biological Sensing
25 Oct 2005 | | Contributor(s):: Gil Lee
Nanoparticles have unique physical and chemical properties that make them very useful for biological and chemical sensing. For example, colloidal gold has been used as an optical transducer for antibody based sensing for over twenty years and is the basis for a many of the point-of-use...
Nanostructure Engineered Sensors for Gas Detection in Space and Terrestrial Applications
28 Jul 2005 |
A nanosensor technology has been developed using single walled carbon nanotubes (SWNTs) on a pair of interdigitated electrodes (IDE) processed with a silicon-based microfabrication and micromachining technique. These sensors have been exposed to nitrogen dioxide, methane, acetone, benzene,...
Top-Metal/Molecular Monolayer Interactions and Final Device Performance
28 Jul 2005 | | Contributor(s):: Curt A Richter
The top-metal/molecular-monolayer interface is of critical importance in the formation of molecular electronic (ME) devices and test structures. I will discuss two experimental studies of ME devices in which the final device performance can be attributed to top-metal/molecule interactions:...
Organic Electronics Part II: Electric Field Modulation
A solid state platform has been designed and fabricated that allows characterization of candidate organic semiconductor materials used in organic field-effect transistors (OFET). A systematic experimental protocol has been outlined that allows the separation of contribution of contact resistance...
Novel Magnetic Materials for Biomolecular Diagnostics
28 Jul 2005 | | Contributor(s):: Gil Lee, David Janes, Sugata Bhattacharya, Kyung Jae Jeong, ,
Paramagnetic particles have emerged as important tools for cell sorting,protein separation, and single molecule measurements. The particles used inthese applications must meet the following requirements: uniform in size,highly paramagnetic, stable in physiological salt buffer, functionizable,and...
Electrical Conduction through dsDNA-Molecule with Nanoscale Break Junctions
28 Jul 2005 | | Contributor(s):: Ajit Kumar Mahapatro, Kyung Jae Jeong, Sugata Bhattacharya, Gil Lee, David Janes
Measuring the electrical conductivity through a specific strand of DNA is of great interest to the nano-science and engineering community. This work focuses on the electrical conduction through 15 base-pair, double helix oligo-nucleotides with various sequences. The current-voltage...
Basic Electronic Properties of DNA
28 Jul 2005 | | Contributor(s):: M. P. Anantram
DNA Charge Motion: Regimes and Behaviors
28 Jul 2005 | | Contributor(s):: Mark Ratner
Because DNA is a quasi-one-dimensional species, and because each base is a pi-type chromphore, it was long ago suggested that DNA could conduct electricity. This has become a widely investigated area, and remains of interest for fundamental science and for applications. We will discuss a very...
Tuning of Electronic Properties of Organic Semiconductors...
27 Jul 2005 |
Intrinsic conducting polymers are key components in organic electronic devices. These materials are also known to be sensitive toward a variety of gases and vapors, which can be exploited by incorporation as chemical sensitive element in a nanoscale sensing system. The molecular interaction...
Organic Electronics Part I: Chemical Modulation
Organic semiconductors (OS) have been in the center of attention in at least two areas: in chemical ,sensors and in molecular electronics. Although the chemistry and physics governing them is the same their performance characteristics are apparently measured on different scales. Electrochemical...
Nanofactories - In - Situ Production of Therapeutic Genes...
27 Jul 2005 | | Contributor(s):: James Leary
A New Terahertz Heterodyne Detector Based on Single-Walled Carbon Nanotubes
We present non-invasive methods for improving the sensitivity of label-free biosensors that offer the advantage of rapid and real-time detection but suffer from relatively low sensitivity. We present detection of cancer markers using the Quartz Crystal Microbalance and demonstrate that 2...
Sensitivity Amplification in Biosensors using Nanoparticles and Enzymatic Macromolecules
27 Jul 2005 | | Contributor(s):: Cagri Savran
Fine Tuning Microcantilever Vibrations for Ultrasensitive Analyte Mass Detection
27 Jul 2005 | | Contributor(s):: Arvind Raman
Microcantilever based biochemical sensing has shown tremendous promise for ultrasenstive detection in both liquid and ambient conditions. However improving the sensitivity, reliability and robustness of these sensors so they can achieve their potential needs substantial efforts in (a) chemical...
A Novel Diagnostic Assay Based On Nanomechanics
Micro-fabricated silicon cantilevers arrays offer a novel label-free approach where ligand-receptor binding interactions occurring on the sensor generate nanomechanical signals like bending or a change in mass that is optically detected in-situ. We report the detection of multiple unlabelled...