BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo

26 Sep 2007 | Online Presentations | Contributor(s): James Leary

Outline: Assessing nanomedical system (NMS) targeting at the single cell level Fluorescent labeling of NMSs First estimates of NMS binding by fluorescence microscopy Internal of external binding …

https://nanohub.org/resources/3240

BME 695N Lecture 10: Nanomaterials for core design

26 Sep 2007 | Online Presentations | Contributor(s): James Leary

Outline: Introduction Core building blocks Functional cores Functionalizing the core surface Ferric oxide cores Paramagnetic cores Superparamagnetic cores Ferric nanorods Advantages and …

https://nanohub.org/resources/3313

BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells

24 Sep 2007 | Online Presentations | Contributor(s): James Leary

Outline: Introduction to measuring technologies for nanomedical system interaction with cells The importance of quantitative or at least semi-quantitative single cell measurements to detect …

https://nanohub.org/resources/3265

BME 695N Lecture 7: Normal & facilitated cell entry mechanisms

15 Sep 2007 | Online Presentations | Contributor(s): James Leary

Outline: Introduction The general problem of cell entry Choosing modes of cell entry How does Nature do it? (biomimetics) Non-specific uptake mechanisms Pinocytosis by all cells …

https://nanohub.org/resources/3241

BME 695N Lecture 5: Cell Targeting

12 Sep 2007 | Online Presentations | Contributor(s): James Leary

Outline: Overview: targeting nanosystems to cells Antibody targeting Peptide targeting Aptamer targeting Antibodies – polyclonal and monoclonal Where do antibodies come from – in …

https://nanohub.org/resources/3176

BME 695N Lecture 4: Designing "Theragnostic" Systems

04 Sep 2007 | Online Presentations | Contributor(s): James Leary

Outline: Bridging the gap between diagnostics and therapeutics How conventional medicine is practiced in terms of diagnostics and therapeutics The consequences of separating diagnostics and …

https://nanohub.org/resources/3109

BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design

29 Aug 2007 | Online Presentations | Contributor(s): James Leary

Outline: Nanomedical systems – levels of challenges Essential elements of a nanomedical system Requirements for specific cell targeting Consequences of mis-targeting Engineering around the …

https://nanohub.org/resources/3108

BME 695N Lecture 2: Basic Concepts of Nanomedical Systems

28 Aug 2007 | Online Presentations | Contributor(s): James Leary

Outline: Features of Nanomedicine Bottoms up rather than top down approach to medicine Nano-tools on the scale of molecules Cell-by-cell repair approach – regenerative medicine Feedback …

https://nanohub.org/resources/3095

Re-engineering a Healthy Eye Tissue to Restore Damaged Eyesight

02 Aug 2007 | Online Presentations | Contributor(s): Margarita Shalaev

Age-related macular degeneration (AMD) is an eye disease that is the leading cause of blindness in the USA and Western Europe. It affects over one million people in the United States alone. One of …

https://nanohub.org/resources/3011

Biosensing applications of Plasmon Resonance in gold nanoparticles

02 Aug 2007 | Online Presentations | Contributor(s): Karina Moore

Light can be used to excite plasmon resonance in gold nanoparticles. Plasmon resonance occurs on the nanoscale as the particles become excited and plasmon oscillations arise in each particle of a …

https://nanohub.org/resources/3019

BME 695N Lecture 1: Need for New Perspectives on Medicine

03 Aug 2007 | Online Presentations | Contributor(s): James Leary

Outline: The Progression of Medicine Conventional "modern" medicine "Personalized" or "molecular" medicine Nanomedicine "single-cell" medicine How Conventional Medicine Works for Diagnosis of …

https://nanohub.org/resources/3047

Molecular Interferometry

26 Jun 2007 | Online Presentations | Contributor(s): David D. Nolte

While single-molecule detection through fluorescence has now become common-place, there has been no analogous single-molecule capability using direct detection approaches such as interferometry. …

https://nanohub.org/resources/2832

Charge Transfer Across an Energy Transducing Integral Membrane Protein Complex

31 May 2007 | Online Presentations | Contributor(s): William A. Cramer

The cytochrome bc complexes of the mitochondrial respiratory and photosynthetic electron transport chains are hetero-oligomeric integral membrane proteins. These proteins are responsible for most of …

https://nanohub.org/resources/2679

Polymers for nanoparticle and nanocrystal formulations for drug delivery

15 May 2007 | Online Presentations | Contributor(s): Stephen R. Byrn

Nanoparticles hold great promise for drug delivery applications. Nanoparticles might prove to be the only way to bring water insoluble, chemically unstable drugs to market. Because of this, this …

https://nanohub.org/resources/2690

Nanotechnologies, Science and Society: Promises and Challenges

10 May 2007 | Online Presentations | Contributor(s): James Leary

James Leary (2007), "Nanotechnologies, Science and Society: Promises and Challenges," Purdue Bioethics Seminar Series, http://nanohub.org/resources/2691. Bioethics at Purdue The Graduate School …

https://nanohub.org/resources/2691

BNC Annual Research Symposium: Bio-Nanotechnology and Biomedical Devices

23 Apr 2007 | Online Presentations | Contributor(s): Rashid Bashir

This presentation is part of a collection of presentations describing the projects, people, and capabilities enhanced by research performed in the Birck Center, and a look at plans for the upcoming …

https://nanohub.org/resources/2626

High-Aspect-Ratio Micromachining of Titanium: Enabling New Functionality and Opportunity in Micromechanical Systems Through Greater Materials Selection

09 Apr 2007 | Online Presentations | Contributor(s): Masa Rao

Traditionally, materials selection has been limited in high-aspect-ratio micromechanical applications, due primarily to the predominance of microfabrication processes and infrastructure dedicated to …

https://nanohub.org/resources/2590

The Impact of Protein Flexibility on Ligand Binding to Proteins: A Computational Perspective

22 Mar 2007 | Online Presentations | Contributor(s): Markus A. Lill

Nowadays, computer-aided drug discovery (CADD) concepts are routinely used in academia and industry for identifying and optimizing lead structures. While CADD techniques have been widely used to …

https://nanohub.org/resources/2472

Antiestrogenic Conjugates as New Breast Cancer Chemoprevention Agents

08 Mar 2007 | Online Presentations | Contributor(s): Ross Weatherman

Tamoxifen is the first drug specifically approved for the prevention of cancer and arguably the most successful anticancer drug of all time. Although millions of breast cancer patients have benefited …

https://nanohub.org/resources/2366

Introduction to X-ray Photoelectron Spectroscopy and XPS Application for Biologically Related Objects

14 Feb 2007 | Online Presentations | Contributor(s): Dmitry Zemlyanov

X-ray Photoelectron Spectroscopy (XPS), which is known as Electron Spectroscopy for Chemical Analysis (ESCA), is a powerful research tool for the study of the surface of solids. The technique …

https://nanohub.org/resources/2335