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Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology. Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials. More information on Nanomedicine can be found here.
BME 695N Lecture 10: Nanomaterials for core design
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26 Sep 2007 | | Contributor(s):: James Leary
Outline:IntroductionCore building blocksFunctional coresFunctionalizing the core surfaceFerric oxide coresParamagnetic coresSuperparamagnetic coresFerric nanorodsAdvantages and disadvantagesC60 and carbon nanotubesSize and structure of C60Elongation of C60 into carbon nanotubesAdvantages and...
BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells
24 Sep 2007 | | Contributor(s):: James Leary
Outline:Introduction to measuring technologies for nanomedical system interaction with cellsThe importance of quantitative or at least semi-quantitative single cell measurementsto detect presence and location of nanomedical systemsBelow "optical limit" imagingRequirements on the NMS to have...
BME 695N Lecture 7: Normal & facilitated cell entry mechanisms
15 Sep 2007 | | Contributor(s):: James Leary
Outline:IntroductionThe general problem of cell entryChoosing modes of cell entryHow does Nature do it? (biomimetics)Non-specific uptake mechanismsPinocytosis by all cellsPhagocytosis by some cellsReceptor mediated uptakeReceptor mediated transport of desired moleculesExample- transferrin...
BME 695N Lecture 5: Cell Targeting
12 Sep 2007 | | Contributor(s):: James Leary
Outline:Overview: targeting nanosystems to cellsAntibody targetingPeptide targetingAptamer targetingAntibodies – polyclonal and monoclonalWhere do antibodies come from – in nature?How do we make them in the laboratory?Monoclonal antibodiesTherapy problems with mouse monoclonal...
BME 695N Lecture 4: Designing "Theragnostic" Systems
04 Sep 2007 | | Contributor(s):: James Leary
Outline:Bridging the gap between diagnostics and therapeuticsHow conventional medicine is practiced in terms of diagnostics and therapeuticsThe consequences of separating diagnostics and therapeuticsA new approach – "theragnostics" (or "theranostics")Examples of current theragnostic...
BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design
29 Aug 2007 | | Contributor(s):: James Leary
Outline:Nanomedical systems – levels of challengesEssential elements of a nanomedical systemRequirements for specific cell targetingConsequences of mis-targetingEngineering around the consequences of mis-targetingSome ways to lower mis-targeting to non-diseased cells
BME 695N Lecture 2: Basic Concepts of Nanomedical Systems
28 Aug 2007 | | Contributor(s):: James Leary
Outline: Features of NanomedicineBottoms up rather than top down approach to medicine Nano-tools on the scale of molecules Cell-by-cell repair approach – regenerative medicine Feedback control system to control drug dosing Elements of good engineering designWhenever possible, use a general...
Re-engineering a Healthy Eye Tissue to Restore Damaged Eyesight
02 Aug 2007 | | Contributor(s):: Margarita Shalaev
Age-related macular degeneration (AMD) is an eye disease that is the leading cause of blindness in the USA and Western Europe. It affects over one million people in the United States alone. One of the symptoms of AMD is a diseased Bruch’s membrane, which is an important layer in the eye. Our...
Biosensing applications of Plasmon Resonance in gold nanoparticles
02 Aug 2007 | | Contributor(s):: Karina Moore
Light can be used to excite plasmon resonance in gold nanoparticles. Plasmon resonance occurs on the nanoscale as the particles become excited and plasmon oscillations arise in each particle of a pair of metal nanoparticles. There is plasmon coupling between the neighboring particles as the...
BME 695N Lecture 1: Need for New Perspectives on Medicine
03 Aug 2007 | | Contributor(s):: James Leary
Outline:The Progression of MedicineConventional "modern" medicine "Personalized" or "molecular" medicineNanomedicine "single-cell" medicineHow Conventional Medicine Works for Diagnosis of DiseaseIdentification of the "diseased state"Simple measurements of body structure and functionFollow-up...
26 Jun 2007 | | Contributor(s):: David D. Nolte
While single-molecule detection through fluorescence has now become common-place, there has been no analogous single-molecule capability using direct detection approaches such as interferometry. This limitation is slowly yielding to high-speed interferoemtric detection that is pushing the...
Charge Transfer Across an Energy Transducing Integral Membrane Protein Complex
31 May 2007 | | Contributor(s):: William A. Cramer
The cytochrome bc complexes of the mitochondrial respiratory and photosynthetic electron transport chains are hetero-oligomeric integral membrane proteins. These proteins are responsible for most of the energy transduction and transport activities across biological membranes. Such complexes...
Polymers for nanoparticle and nanocrystal formulations for drug delivery
15 May 2007 | | Contributor(s):: Stephen R. Byrn
Nanoparticles hold great promise for drug delivery applications. Nanoparticles might prove to be the only way to bring water insoluble, chemically unstable drugs to market. Because of this, this seminar will summarize the use of polymers to prepare and/or coat nanoparticles. Preliminary studies...
Nanotechnologies, Science and Society: Promises and Challenges
10 May 2007 | | Contributor(s):: James Leary
BNC Annual Research Symposium: Bio-Nanotechnology and Biomedical Devices
23 Apr 2007 | | Contributor(s):: Rashid Bashir
This presentation is part of a collection of presentations describing the projects, people, and capabilities enhanced by research performed in the Birck Center, and a look at plans for the upcoming year.
High-Aspect-Ratio Micromachining of Titanium: Enabling New Functionality and Opportunity in Micromechanical Systems Through Greater Materials Selection
09 Apr 2007 | | Contributor(s):: Masa Rao
Traditionally, materials selection has been limited in high-aspect-ratio micromechanical applications, due primarily to the predominance of microfabrication processes and infrastructure dedicated to silicon. While silicon has proven to be an excellent material for many of these applications, no...
The Impact of Protein Flexibility on Ligand Binding to Proteins: A Computational Perspective
22 Mar 2007 | | Contributor(s):: Markus A. Lill
Nowadays, computer-aided drug discovery (CADD) concepts are routinely used in academia and industry for identifying and optimizing lead structures. While CADD techniques have been widely used to attain a qualitative understanding of ligand binding to proteins, a current challenge is to quantify...
Antiestrogenic Conjugates as New Breast Cancer Chemoprevention Agents
08 Mar 2007 | | Contributor(s):: Ross Weatherman
Tamoxifen is the first drug specifically approved for the prevention of cancer and arguably the most successful anticancer drug of all time. Although millions of breast cancer patients have benefited from tamoxifen therapy, there are side effects that hinder the broad use of tamoxifen as a...
Introduction to X-ray Photoelectron Spectroscopy and XPS Application for Biologically Related Objects
14 Feb 2007 | | Contributor(s):: Dmitry Zemlyanov
X-ray Photoelectron Spectroscopy (XPS), which is known as Electron Spectroscopy for Chemical Analysis (ESCA), is a powerful research tool for the study of the surface of solids. The technique becomes widely used for studies of the properties of atoms, molecules, solids, and surfaces. The main...
Nanoparticles in Biology and Materials: Engineering the Interface through Synthesis
29 Jan 2007 | | Contributor(s)::
Monolayer-protected nanoparticles provide versatile tools for nanotechnology. In our research, we use these nanoparticles as building blocks for the creation of functional magnetic and electronic nanocomposite materials. Simultaneously, we are using these particles as scaffolds for biomolecular...